DegronMD

Uniprot ID: Q9P2F8

Source protein: Signal-induced proliferation-associated 1-like protein 2

Source gene: SIPA1L2

Class: DEG_SCF_TRCP1_1

Location: 1264:1269

E3 ligase: BTRC

DEGRON score: 0.9983

ASA_SCORE: 65.9833

COIL: 0.88

CONS_SCORE: 0.3609

DSS_SCORE: 0.3426

HELIX: 0.0527

FCONS_SCORE: 1.0005

RIG_SCORE: 0.732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1258F	TCGA-43-5668	LUSC	TCGA	DSGIDT	DEG_SCF_TRCP1_1	0.1667
p.I1258F	DO26608	LUSC	ICGC	DSGIDT	DEG_SCF_TRCP1_1	0.1667
p.D1264N	TCGA-55-A4DF	LUAD	TCGA	DSGIDT	DEG_SCF_TRCP1_1	0.6932
p.D1264N	TCGA-LN-A4A2	ESCA	TCGA	DSGIDT	DEG_SCF_TRCP1_1	0.6932
p.D1264N	DO227709	COCA	ICGC	DSGIDT	DEG_SCF_TRCP1_1	0.6932
p.D1264N	DO45318	LUAD	ICGC	DSGIDT	DEG_SCF_TRCP1_1	0.6932
p.M1273V	TCGA-66-2755	LUSC	TCGA	DSGIDT	DEG_SCF_TRCP1_1	0.2222
p.M1273V	DO27365	LUSC	ICGC	DSGIDT	DEG_SCF_TRCP1_1	0.2222
p.D1268N	TCGA-D1-A17Q	UCEC	TCGA	DSGIDT	DEG_SCF_TRCP1_1	0.5821
p.D1268N	DO41903	UCEC	ICGC	DSGIDT	DEG_SCF_TRCP1_1	0.5821
p.D1268H	DO229493	LAML	ICGC	DSGIDT	DEG_SCF_TRCP1_1	0.6577
p.T1263S	DO35350	PACA	ICGC	DSGIDT	DEG_SCF_TRCP1_1	0.3056
p.I1258V	SIDM00663	Melanoma	GDSC	DSGIDT	DEG_SCF_TRCP1_1	0.1667
p.I1258V	ACH-000814	Skin Cancer	CCLE	DSGIDT	DEG_SCF_TRCP1_1	0.1667
p.I1258V	Hs939-T	skin	COSMIC	DSGIDT	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SCF_TRCP1_1	1264:1269	DSGIDT	BTRC	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons