DegronMD

Uniprot ID: Q9P2F8

Source protein: Signal-induced proliferation-associated 1-like protein 2

Source gene: SIPA1L2

Class: DEG_SPOP_SBC_1

Location: 429:433

E3 ligase: SPOP

DEGRON score: 0.756

ASA_SCORE: 66.96

COIL: 0.7958

CONS_SCORE: 0.389

DSS_SCORE: 0.3528

HELIX: 0.1354

FCONS_SCORE: 0.9214

RIG_SCORE: 0.6551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I424S	TCGA-AA-3815	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1944
p.I424S	DO9924	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1944
p.S431L	TCGA-D1-A16J	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.7667
p.S431L	DO43033	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.7667
p.N430K	TCGA-D6-6516	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.5806
p.N430K	DO15623	HNSC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.5806
p.N430T	TCGA-D6-6516	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.5944
p.N430T	DO15623	HNSC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.5944
p.E419K	TCGA-HU-A4GT	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.0556
p.E419K	DO48020	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.R423Q	SIDM00475	Ovarian Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.1667
p.R423Q	ACH-000091	Ovarian Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	0.1667
p.R423Q	OV-56	ovary	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.1667
p.S439L	C-4-I	cervix	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	213:217	ANSSS	SPOP	0.9966	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1879:1883	ANSSS	SPOP	0.986	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1021:1025	ANSSS	SPOP	0.9968	More...
Q06945	Transcription factor SOX-4	DEG_SPOP_SBC_1	139:143	ANSSS	SPOP	0.9719	More...
Q6UWB1	Interleukin-27 receptor subunit alpha	DEG_SPOP_SBC_1	562:566	ANSSS	SPOP	0.7903	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	551:555	ANSSS	SPOP	0.983	More...
Q8IZW8	Tensin-4	DEG_SPOP_SBC_1	311:315	ANSSS	SPOP	0.8185	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	720:724	ANSSS	SPOP	0.9105	More...
Q9BRS8	La-related protein 6	DEG_SPOP_SBC_1	336:340	ANSSS	SPOP	0.9686	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	446:450	ANSSS	SPOP	0.8794	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_SPOP_SBC_1	729:733	ANSSS	SPOP	0.8431	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	73:77	ANSSS	SPOP	0.9841	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_SPOP_SBC_1	775:779	ANSSS	SPOP	0.9091	More...
Q9H1C0	Lysophosphatidic acid receptor 5	DEG_SPOP_SBC_1	3:7	ANSSS	SPOP	0.6526	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	429:433	ANSSS	SPOP	0.756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons