DegronMD

Uniprot ID: Q9HCD5

Source protein: Nuclear receptor coactivator 5

Source gene: NCOA5

Class: DEG_SPOP_SBC_1

Location: 446:450

E3 ligase: SPOP

DEGRON score: 0.8794

ASA_SCORE: 86.24

COIL: 0.9184

CONS_SCORE: 0.3001

DSS_SCORE: 0.4793

HELIX: 0.0662

FCONS_SCORE: 0.9336

RIG_SCORE: 0.6162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S454L	TCGA-AB-2828	LAML	TCGA	ANSSS	DEG_SPOP_SBC_1	0.2222
p.S454L	DO21571	LAML	ICGC	ANSSS	DEG_SPOP_SBC_1	0.2222
p.A456V	TCGA-CM-6674	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1667
p.A456V	DO10092	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1667
p.P453S	TCGA-D3-A5GS	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	0.25
p.P453S	DO47706	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	0.25
p.L436I	TCGA-DU-6392	LGG	TCGA	ANSSS	DEG_SPOP_SBC_1	0.0556
p.L436I	DO22237	LGG	ICGC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.V444M	TCGA-EO-A22U	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.2778
p.V444M	DO43755	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.2778
p.S450Y	TCGA-FI-A2D5	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.712
p.S450Y	DO41331	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.712
p.A451E	DO229019	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	0.3056
p.A451T	SIDM00113	Kidney Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.3056
p.A451T	TK10	kidney	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	213:217	ANSSS	SPOP	0.9966	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1879:1883	ANSSS	SPOP	0.986	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1021:1025	ANSSS	SPOP	0.9968	More...
Q06945	Transcription factor SOX-4	DEG_SPOP_SBC_1	139:143	ANSSS	SPOP	0.9719	More...
Q6UWB1	Interleukin-27 receptor subunit alpha	DEG_SPOP_SBC_1	562:566	ANSSS	SPOP	0.7903	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	551:555	ANSSS	SPOP	0.983	More...
Q8IZW8	Tensin-4	DEG_SPOP_SBC_1	311:315	ANSSS	SPOP	0.8185	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	720:724	ANSSS	SPOP	0.9105	More...
Q9BRS8	La-related protein 6	DEG_SPOP_SBC_1	336:340	ANSSS	SPOP	0.9686	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	446:450	ANSSS	SPOP	0.8794	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_SPOP_SBC_1	729:733	ANSSS	SPOP	0.8431	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	73:77	ANSSS	SPOP	0.9841	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_SPOP_SBC_1	775:779	ANSSS	SPOP	0.9091	More...
Q9H1C0	Lysophosphatidic acid receptor 5	DEG_SPOP_SBC_1	3:7	ANSSS	SPOP	0.6526	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	429:433	ANSSS	SPOP	0.756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons