DegronMD - Q9HCD5(NCOA5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S530C	TCGA-34-5236	LUSC	TCGA	PVSST	DEG_SPOP_SBC_1	527:531	Mutation altering degron motif	0.7541
p.S530C	DO26778	LUSC	ICGC	PVSST	DEG_SPOP_SBC_1	527:531	Mutation altering degron motif	0.7541
p.S454L	TCGA-AB-2828	LAML	TCGA	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.S454L	DO21571	LAML	ICGC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.A456V	TCGA-CM-6674	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.A456V	DO10092	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.P453S	TCGA-D3-A5GS	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.P453S	DO47706	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.L436I	TCGA-DU-6392	LGG	TCGA	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.L436I	DO22237	LGG	ICGC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.P538S	TCGA-EE-A2MR	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1389
p.P538S	DO37819	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1389
p.V444M	TCGA-EO-A22U	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.V444M	DO43755	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.S450Y	TCGA-FI-A2D5	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.712
p.S450Y	DO41331	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.712
p.D536H	DO10840	ESAD	ICGC	PVSST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1944
p.R526S	DO233290	GACA	ICGC	PVSST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.3056
p.A451E	DO229019	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.P407T	DO229032	LICA	ICGC	PSATPTPS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1111
p.S422A	SIDM00845	Burkitt's Lymphoma	GDSC	PSATPTPS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7588
p.S422A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSATPTPS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7588
p.S422A	SIDM01519	Head and Neck Carcinoma	GDSC	PSATPTPS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7588
p.S422A	ACH-000786	Lymphoma	CCLE	PSATPTPS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7588
p.A451T	SIDM00113	Kidney Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.A451T	TK10	kidney	COSMIC	ANSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.P421L	ACH-002396	Bone Cancer	CCLE	PSATPTPS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.6471
p.P421L	Sarc9371	bone	COSMIC	PSATPTPS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.6471

Kaplan plot for NCOA5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOA5

UniProt ID: Q9HCD5

Entrez ID: 57727

Protein name: Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOA5 in