DegronMD

Uniprot ID: Q9HCD5

Source protein: Nuclear receptor coactivator 5

Source gene: NCOA5

Class: DEG_SCF_FBW7_1

Location: 415:422

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 88.95

COIL: 0.9669

CONS_SCORE: 0.3164

DSS_SCORE: 0.7499

HELIX: 0.0128

FCONS_SCORE: 0.9976

RIG_SCORE: 0.5804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P407T	DO229032	LICA	ICGC	PSATPTPS	DEG_SCF_FBW7_1	0.1111
p.S422A	SIDM00845	Burkitt's Lymphoma	GDSC	PSATPTPS	DEG_SCF_FBW7_1	0.7588
p.S422A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSATPTPS	DEG_SCF_FBW7_1	0.7588
p.S422A	SIDM01519	Head and Neck Carcinoma	GDSC	PSATPTPS	DEG_SCF_FBW7_1	0.7588
p.S422A	ACH-000786	Lymphoma	CCLE	PSATPTPS	DEG_SCF_FBW7_1	0.7588
p.P421L	ACH-002396	Bone Cancer	CCLE	PSATPTPS	DEG_SCF_FBW7_1	0.6471
p.P421L	Sarc9371	bone	COSMIC	PSATPTPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCD5	Nuclear receptor coactivator 5	DEG_SCF_FBW7_1	415:422	PSATPTPS	FBXW7	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons