DegronMD - Q9Y4F3(MARF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D782N	SIDM00313	Hodgkin's Lymphoma	GDSC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.25
p.D782N	L-1236	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.25
p.S687L	SIDM00319	Melanoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation altering degron motif	0.7667
p.R804Q	SIDM00393	Gastric Carcinoma	GDSC	DYR	CBL_MET	799:801	Mutation rewiring degron network	0.25
p.R804Q	SK-GT-2	stomach	COSMIC	DYR	CBL_MET	799:801	Mutation rewiring degron network	0.25
p.G790R	SIDM00619	Thyroid Gland Carcinoma	GDSC	DYR	CBL_MET	799:801	Mutation rewiring degron network	0.0833
p.G790R	KMH-2	thyroid	COSMIC	DYR	CBL_MET	799:801	Mutation rewiring degron network	0.0833
p.S702T	SIDM00878	Breast Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.S702T	SIDM00878	Breast Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.0556
p.S702T	SIDM00879	Breast Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.S702T	SIDM00879	Breast Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.0556
p.S702T	SIDM00254	Neuroblastoma	GDSC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.S702T	SIDM00254	Neuroblastoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.0556
p.S702T	SIDM01318	Hepatocellular Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.S702T	SIDM01318	Hepatocellular Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.0556
p.S702T	SIDM01387	Small Cell Lung Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.S702T	SIDM01387	Small Cell Lung Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.0556
p.P769L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.P769L	DND-41	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.V698I	SIDM00980	Gastric Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1667
p.V698I	SIDM00980	Gastric Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.1667
p.V698I	23132-87	stomach	COSMIC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1667
p.V698I	23132-87	stomach	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.1667
p.Q787K	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1111
p.K696R	KS-1	central nervous system	COSMIC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1111
p.K696R	KS-1	central nervous system	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.2222
p.R768W	SNU-175	large intestine	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation blocking phosphorylation signal	0.5833
p.R768W	SK-UT-1	soft tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation blocking phosphorylation signal	0.5833
p.R801Q	SK-GT-2	stomach	COSMIC	DYR	CBL_MET	799:801	Mutation altering degron motif	0.7329
p.D779N	L-1236	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.6932
p.G791S	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	799:801	Mutation rewiring degron network	0.1111
p.C771F	HCC-15	lung	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.2222
p.G787R	KMH-2	thyroid	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1111
p.G705R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.7568
p.V695I	23132-87	stomach	COSMIC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.0833
p.V695I	23132-87	stomach	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.25
p.P766L	DND-41	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.V697I	23132-87	stomach	COSMIC	KKENL	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1389
p.V697I	23132-87	stomach	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	686:692	Mutation rewiring degron network	0.1944

Kaplan plot for MARF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MARF1

UniProt ID: Q9Y4F3

Entrez ID: 9665

Protein name: Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MARF1 in