DegronMD

Uniprot ID: Q9Y4F3

Source protein: Meiosis regulator and mRNA stability factor 1

Source gene: MARF1

Class: DEG_SCF_FBW7_1

Location: 686:692

E3 ligase: FBXW7

DEGRON score: 0.9687

ASA_SCORE: 84.6286

COIL: 0.9004

CONS_SCORE: 0.3062

DSS_SCORE: 0.6034

HELIX: 0.0217

FCONS_SCORE: 0.908

RIG_SCORE: 0.6287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S687L	SIDM00319	Melanoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	0.7667
p.S702T	SIDM00878	Breast Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	0.0556
p.S702T	SIDM00879	Breast Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	0.0556
p.S702T	SIDM00254	Neuroblastoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	0.0556
p.S702T	SIDM01318	Hepatocellular Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	0.0556
p.S702T	SIDM01387	Small Cell Lung Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	0.0556
p.V698I	SIDM00980	Gastric Carcinoma	GDSC	VSTPKNS	DEG_SCF_FBW7_1	0.1667
p.V698I	23132-87	stomach	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	0.1667
p.K696R	KS-1	central_nervous_system	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	0.2222
p.V695I	23132-87	stomach	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	0.25
p.V697I	23132-87	stomach	COSMIC	VSTPKNS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_SCF_FBW7_1	686:692	VSTPKNS	FBXW7	0.9687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons