DegronMD

Uniprot ID: Q9Y4F3

Source protein: Meiosis regulator and mRNA stability factor 1

Source gene: MARF1

Class: DEG_APCC_KENBOX_2

Location: 704:708

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 103.96

COIL: 0.5916

CONS_SCORE: 0.3742

DSS_SCORE: 0.5007

HELIX: 0.3814

FCONS_SCORE: 1.0584

RIG_SCORE: 0.6944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S702T	SIDM00878	Breast Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.S702T	SIDM00879	Breast Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.S702T	SIDM00254	Neuroblastoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.S702T	SIDM01318	Hepatocellular Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.S702T	SIDM01387	Small Cell Lung Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.V698I	SIDM00980	Gastric Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.1667
p.V698I	23132-87	stomach	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.1667
p.K696R	KS-1	central_nervous_system	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.1111
p.G705R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.7568
p.V695I	23132-87	stomach	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.0833
p.V697I	23132-87	stomach	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0W9	Protein FAM83B	DEG_APCC_KENBOX_2	785:789	KKENL	APC,CDC20,FZR1	0.9502	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_APCC_KENBOX_2	704:708	KKENL	APC,CDC20,FZR1	0.9956	More...
Q6ZP01	RNA-binding protein 44	DEG_APCC_KENBOX_2	32:36	KKENL	APC,CDC20,FZR1	0.7572	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	261:265	KKENL	APC,CDC20,FZR1	0.8711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons