DegronMD

Uniprot ID: Q6ZP01

Source protein: RNA-binding protein 44

Source gene: RBM44

Class: DEG_APCC_KENBOX_2

Location: 32:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7572

ASA_SCORE: 89.54

COIL: 0.512

CONS_SCORE: 0.5338

DSS_SCORE: 0.6247

HELIX: 0.2626

FCONS_SCORE: 1.158

RIG_SCORE: 0.7229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G42S	TCGA-C8-A1HM	BRCA	TCGA	KKENL	DEG_APCC_KENBOX_2	0.1667
p.G42S	DO3904	BRCA	ICGC	KKENL	DEG_APCC_KENBOX_2	0.1667
p.K32N	TCGA-D1-A16X	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	0.5806
p.K32N	DO41799	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	0.5806
p.S40Y	TCGA-D3-A3CB	SKCM	TCGA	KKENL	DEG_APCC_KENBOX_2	0.2222
p.S40Y	DO47386	SKCM	ICGC	KKENL	DEG_APCC_KENBOX_2	0.2222
p.L36V	TCGA-EO-A22X	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	0.5654
p.L36V	DO43907	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	0.5654
p.C43F	DO228985	LICA	ICGC	KKENL	DEG_APCC_KENBOX_2	0.1389
p.S39F	DO222702	MELA	ICGC	KKENL	DEG_APCC_KENBOX_2	0.25
p.N30T	SIDM00118	Colorectal Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.N30T	ACH-001081	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.2778
p.N30T	HCC2998	large_intestine	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.L23P	SF268	central_nervous_system	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0W9	Protein FAM83B	DEG_APCC_KENBOX_2	785:789	KKENL	APC,CDC20,FZR1	0.9502	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_APCC_KENBOX_2	704:708	KKENL	APC,CDC20,FZR1	0.9956	More...
Q6ZP01	RNA-binding protein 44	DEG_APCC_KENBOX_2	32:36	KKENL	APC,CDC20,FZR1	0.7572	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	261:265	KKENL	APC,CDC20,FZR1	0.8711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons