DegronMD

Uniprot ID: Q5T0W9

Source protein: Protein FAM83B

Source gene: FAM83B

Class: DEG_APCC_KENBOX_2

Location: 785:789

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9502

ASA_SCORE: 109.26

COIL: 0.6908

CONS_SCORE: 0.7235

DSS_SCORE: 0.4659

HELIX: 0.2974

FCONS_SCORE: 0.8848

RIG_SCORE: 0.7221

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L789I	TCGA-AN-A046	BRCA	TCGA	KKENL	DEG_APCC_KENBOX_2	0.6063
p.L789I	DO1285	BRCA	ICGC	KKENL	DEG_APCC_KENBOX_2	0.6063
p.A796V	DO231906	LINC	ICGC	KKENL	DEG_APCC_KENBOX_2	0.1389
p.S790F	SIDM00545	Melanoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.3056
p.S790F	SIDM00527	Colorectal Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.3056
p.S790F	ACH-000935	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.3056
p.S790F	ACH-000987	Skin Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.3056
p.S790F	Mewo	skin	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.3056
p.S790F	MDST8	large_intestine	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.3056
p.A794S	SIDM00198	Ewing's Sarcoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.1944
p.A794S	ACH-002114	Bone Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.1944
p.A794S	EW-16	bone	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.1944
p.P783S	SIDM01133	Other Solid Cancers	GDSC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.P783S	ACH-002177	Lung Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.2778
p.P783S	NCI-H835	lung	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.S790P	ACH-001607	Gallbladder Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0W9	Protein FAM83B	DEG_APCC_KENBOX_2	785:789	KKENL	APC,CDC20,FZR1	0.9502	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_APCC_KENBOX_2	704:708	KKENL	APC,CDC20,FZR1	0.9956	More...
Q6ZP01	RNA-binding protein 44	DEG_APCC_KENBOX_2	32:36	KKENL	APC,CDC20,FZR1	0.7572	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	261:265	KKENL	APC,CDC20,FZR1	0.8711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons