DegronMD

Uniprot ID: Q8N9V7

Source protein: Protein TOPAZ1

Source gene: TOPAZ1

Class: DEG_APCC_KENBOX_2

Location: 261:265

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8711

ASA_SCORE: 113.98

COIL: 0.6936

CONS_SCORE: 0.861

DSS_SCORE: 0.4192

HELIX: 0.2482

FCONS_SCORE: 1.1758

RIG_SCORE: 0.733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N258K	TCGA-B5-A3FA	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	0.25
p.N258K	DO52402	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	0.25
p.D273G	TCGA-D1-A16R	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	0.1111
p.D273G	DO41831	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	0.1111
p.F259L	TCGA-D1-A16X	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	0.2778
p.F259L	DO41799	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.F259V	TCGA-F5-6814	READ	TCGA	KKENL	DEG_APCC_KENBOX_2	0.2778
p.F259V	DO36556	READ	ICGC	KKENL	DEG_APCC_KENBOX_2	0.2778
p.C252F	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.0833
p.C252F	ACH-000706	Lung Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.0833
p.C252F	EKVX	lung	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.0833
p.E263K	SIDM00789	Colorectal Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.7022
p.E263K	ACH-000997	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.7022
p.E263K	ACH-001061	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.7022
p.E263K	HCT-15	large_intestine	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.7022
p.L265F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.587
p.L265F	SIDM00937	Oral Cavity Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.587
p.L265F	CAL-27	upper_aerodigestive_tract	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.587
p.L265F	NCI-H441	lung	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.587
p.K261N	SIDM00272	Breast Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	0.5806
p.K261N	ACH-000910	Breast Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	0.5806
p.K261N	MDA-MB-453	breast	COSMIC	KKENL	DEG_APCC_KENBOX_2	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0W9	Protein FAM83B	DEG_APCC_KENBOX_2	785:789	KKENL	APC,CDC20,FZR1	0.9502	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_APCC_KENBOX_2	704:708	KKENL	APC,CDC20,FZR1	0.9956	More...
Q6ZP01	RNA-binding protein 44	DEG_APCC_KENBOX_2	32:36	KKENL	APC,CDC20,FZR1	0.7572	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	261:265	KKENL	APC,CDC20,FZR1	0.8711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons