DegronMD - Q6ZP01(RBM44)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E142K	TCGA-55-7281	LUAD	TCGA	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.0556
p.E142K	DO25985	LUAD	ICGC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.0556
p.G42S	TCGA-C8-A1HM	BRCA	TCGA	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.1667
p.G42S	DO3904	BRCA	ICGC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.1667
p.K32N	TCGA-D1-A16X	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation altering degron motif	0.5806
p.K32N	DO41799	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation altering degron motif	0.5806
p.S40Y	TCGA-D3-A3CB	SKCM	TCGA	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2222
p.S40Y	DO47386	SKCM	ICGC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2222
p.V138A	TCGA-E7-A85H	BLCA	TCGA	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.1667
p.V138A	DO219018	BLCA	ICGC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.1667
p.L36V	TCGA-EO-A22X	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation altering degron motif	0.5654
p.L36V	DO43907	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation altering degron motif	0.5654
p.C43F	DO228985	LICA	ICGC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.1389
p.S39F	DO222702	MELA	ICGC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.25
p.K123N	DO36556	READ	ICGC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation substituting flanking lysine	0.3333
p.D135N	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.25
p.P129L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation altering degron motif	0.7582
p.P129L	ACH-000637	Esophageal Cancer	CCLE	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation altering degron motif	0.7582
p.P129L	KYSE-520	oesophagus	COSMIC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation altering degron motif	0.7582
p.N30T	SIDM00118	Colorectal Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2778
p.N30T	ACH-001081	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2778
p.N30T	HCC2998	large intestine	COSMIC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2778
p.S126C	SIDM00118	Colorectal Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.3056
p.S126C	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.3056
p.S126C	HCC2998	large intestine	COSMIC	LTPLSS	DEG_SCF_FBW7_1	127:132	Mutation rewiring degron network	0.3056
p.L23P	SF268	central nervous system	COSMIC	KKENL	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.0833

Kaplan plot for RBM44 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM44

UniProt ID: Q6ZP01

Entrez ID: 375316

Protein name: RNA-binding protein 44 (RNA-binding motif protein 44)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM44 in