DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPLSS
Uniprot ID:
Q6ZP01
Source protein:
RNA-binding protein 44
Source gene:
RBM44
Class:
DEG_SCF_FBW7_1
Location:
127:132
E3 ligase:
FBXW7
DEGRON score:
0.87
ASA_SCORE:
57.7167
COIL:
0.7133
CONS_SCORE:
0.5343
DSS_SCORE:
0.4196
HELIX:
0.1368
FCONS_SCORE:
0.8999
RIG_SCORE:
0.6928
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P129L
SIDM01025
Esophageal Squamous Cell Carcinoma
GDSC
LTPLSS
DEG_SCF_FBW7_1
0.7582
p.P129L
ACH-000637
Esophageal Cancer
CCLE
LTPLSS
DEG_SCF_FBW7_1
0.7582
p.P129L
KYSE-520
oesophagus
COSMIC
LTPLSS
DEG_SCF_FBW7_1
0.7582
p.K123N
DO36556
READ
ICGC
LTPLSS
DEG_SCF_FBW7_1
0.3333
p.S126C
SIDM00118
Colorectal Carcinoma
GDSC
LTPLSS
DEG_SCF_FBW7_1
0.3056
p.S126C
ACH-001081
Colon/Colorectal Cancer
CCLE
LTPLSS
DEG_SCF_FBW7_1
0.3056
p.S126C
HCC2998
large_intestine
COSMIC
LTPLSS
DEG_SCF_FBW7_1
0.3056
p.D135N
SIDM00438
B-Lymphoblastic Leukemia
GDSC
LTPLSS
DEG_SCF_FBW7_1
0.25
p.V138A
TCGA-E7-A85H
BLCA
TCGA
LTPLSS
DEG_SCF_FBW7_1
0.1667
p.V138A
DO219018
BLCA
ICGC
LTPLSS
DEG_SCF_FBW7_1
0.1667
p.E142K
TCGA-55-7281
LUAD
TCGA
LTPLSS
DEG_SCF_FBW7_1
0.0556
p.E142K
DO25985
LUAD
ICGC
LTPLSS
DEG_SCF_FBW7_1
0.0556
Showing 1 to 12 of 12 entries
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Drug responses associated with RBM44 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of LTPLSS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H2A3
Neurogenin-2
DEG_SCF_FBW7_1
30:35
LTPLSS
FBXW7
0.977
More...
Q9UPX0
Protein turtle homolog B
DEG_SCF_FBW7_1
912:917
LTPLSS
FBXW7
0.9978
More...
Q6ZP01
RNA-binding protein 44
DEG_SCF_FBW7_1
127:132
LTPLSS
FBXW7
0.87
More...
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