DegronMD

Uniprot ID: Q6ZP01

Source protein: RNA-binding protein 44

Source gene: RBM44

Class: DEG_SCF_FBW7_1

Location: 127:132

E3 ligase: FBXW7

DEGRON score: 0.87

ASA_SCORE: 57.7167

COIL: 0.7133

CONS_SCORE: 0.5343

DSS_SCORE: 0.4196

HELIX: 0.1368

FCONS_SCORE: 0.8999

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E142K	TCGA-55-7281	LUAD	TCGA	LTPLSS	DEG_SCF_FBW7_1	0.0556
p.E142K	DO25985	LUAD	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.0556
p.V138A	TCGA-E7-A85H	BLCA	TCGA	LTPLSS	DEG_SCF_FBW7_1	0.1667
p.V138A	DO219018	BLCA	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.1667
p.K123N	DO36556	READ	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.3333
p.D135N	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.25
p.P129L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.7582
p.P129L	ACH-000637	Esophageal Cancer	CCLE	LTPLSS	DEG_SCF_FBW7_1	0.7582
p.P129L	KYSE-520	oesophagus	COSMIC	LTPLSS	DEG_SCF_FBW7_1	0.7582
p.S126C	SIDM00118	Colorectal Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.S126C	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.S126C	HCC2998	large_intestine	COSMIC	LTPLSS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons