DegronMD - Q9UPX0(IGSF9B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1309K	TCGA-21-1079	LUSC	TCGA	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.R1309K	DO26846	LUSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.S990I	TCGA-37-4130	LUSC	TCGA	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1667
p.S990I	DO26490	LUSC	ICGC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1667
p.E938K	TCGA-39-5016	LUSC	TCGA	PPAY	ITCH	925:928	Mutation rewiring degron network	0.0556
p.E938K	TCGA-56-A62T	LUSC	TCGA	PPAY	ITCH	925:928	Mutation rewiring degron network	0.0556
p.E938K	DO26701	LUSC	ICGC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.0556
p.E938K	DO219144	LUSC	ICGC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.0556
p.P926L	TCGA-44-6778	LUAD	TCGA	PPAY	ITCH	925:928	Mutation altering degron motif	0.7582
p.P926L	DO25603	LUAD	ICGC	PPAY	ITCH	925:928	Mutation altering degron motif	0.7582
p.G1159S	TCGA-55-7907	LUAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1111
p.G1159S	DO25396	LUAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1111
p.M1142V	TCGA-55-8089	LUAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.2222
p.M1142V	DO23690	LUAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.2222
p.G1311V	TCGA-78-8662	LUAD	TCGA	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1667
p.G1311V	DO45346	LUAD	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1667
p.S973C	TCGA-85-A4JB	LUSC	TCGA	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.S973C	DO45517	LUSC	ICGC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.E150K	TCGA-A5-A1OF	UCEC	TCGA	PPQY	ITCH	145:148	Mutation rewiring degron network	0.2778
p.E150K	DO42568	UCEC	ICGC	PPQY	ITCH	145:148	Mutation rewiring degron network	0.2778
p.T1323M	TCGA-AA-3530	COAD	TCGA	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation altering degron motif	0.7423
p.T1323M	DO8970	COAD	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation altering degron motif	0.7423
p.P982L	TCGA-AA-3662	COAD	TCGA	PPFY	ITCH	981:984	Mutation altering degron motif	0.7582
p.P982L	DO6958	CLLE	ICGC	PPFY	ITCH	981:984	Mutation altering degron motif	0.7582
p.P982L	DO8336	COAD	ICGC	PPFY	ITCH	981:984	Mutation altering degron motif	0.7582
p.P982L	DO233705	GACA	ICGC	PPFY	ITCH	981:984	Mutation altering degron motif	0.7582
p.G1141V	TCGA-AJ-A3EK	UCEC	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1944
p.G1141V	DO41584	UCEC	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1944
p.G1141V	SIDM01343	Gastric Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1944
p.G1141V	ACH-000764	Gastric Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1944
p.S918I	TCGA-AP-A059	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	914:918	Mutation altering degron motif	0.7341
p.S918I	DO41361	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	914:918	Mutation altering degron motif	0.7341
p.A137D	TCGA-AR-A0U1	BRCA	TCGA	PPQY	ITCH	145:148	Mutation rewiring degron network	0.1111
p.A137D	DO4353	BRCA	ICGC	PPQY	ITCH	145:148	Mutation rewiring degron network	0.1111
p.G1311R	TCGA-BA-A6DA	HNSC	TCGA	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1667
p.G1311R	DO44448	HNSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1667
p.Q1140R	TCGA-BG-A222	UCEC	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1667
p.Q1140R	DO42977	UCEC	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1667
p.G936R	TCGA-BH-A0HF	BRCA	TCGA	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1111
p.G936R	TCGA-EO-A22R	UCEC	TCGA	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1111
p.G936R	DO1749	BRCA	ICGC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1111
p.G936R	DO42713	UCEC	ICGC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1111
p.E1151K	TCGA-CG-4460	STAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation altering degron motif	0.7022
p.E1151K	DO38427	STAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation altering degron motif	0.7022
p.R1136Q	TCGA-CM-6165	COAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.0556
p.R1136Q	DO9900	COAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.0556
p.P926T	TCGA-CR-7370	HNSC	TCGA	PPAY	ITCH	925:928	Mutation altering degron motif	0.7031
p.P926T	DO14426	HNSC	ICGC	PPAY	ITCH	925:928	Mutation altering degron motif	0.7031
p.P982T	TCGA-D3-A3CF	SKCM	TCGA	PPFY	ITCH	981:984	Mutation altering degron motif	0.7031
p.P982T	DO37675	SKCM	ICGC	PPFY	ITCH	981:984	Mutation altering degron motif	0.7031
p.E977K	TCGA-EO-A22U	UCEC	TCGA	PPFY	ITCH	981:984	Mutation rewiring degron network	0.2222
p.E977K	DO43755	UCEC	ICGC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.2222
p.R1316Q	TCGA-EO-A3B0	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.3056
p.R1316Q	DO219773	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.3056
p.P1150S	TCGA-FR-A8YC	SKCM	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation altering degron motif	0.5641
p.P1150S	DO50301	SKCM	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation altering degron motif	0.5641
p.G1160S	TCGA-IB-7651	PAAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.0833
p.G1160S	DO46657	PAAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.0833
p.Q933H	TCGA-IB-7651	PAAD	TCGA	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1944
p.Q933H	DO46657	PAAD	ICGC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1944
p.G1156R	TCGA-IN-A7NU	STAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1944
p.G1156R	DO51746	STAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1944
p.V985M	TCGA-KQ-A41N	BLCA	TCGA	PPFY	ITCH	981:984	Mutation rewiring degron network	0.3056
p.V985M	DO223588	BLCA	ICGC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.3056
p.R931Q	TCGA-L5-A8NM	ESCA	TCGA	PPAY	ITCH	925:928	Mutation rewiring degron network	0.25
p.L912R	TCGA-VQ-A8DZ	STAD	TCGA	LTPLSS	DEG_SCF_FBW7_1	912:917	Mutation altering degron motif	0.8428
p.L912R	DO51755	STAD	ICGC	LTPLSS	DEG_SCF_FBW7_1	912:917	Mutation altering degron motif	0.8428
p.P914S	TCGA-WE-A8ZQ	SKCM	TCGA	LTPLSS	DEG_SCF_FBW7_1	912:917	Mutation altering degron motif	0.6752
p.P914S	TCGA-WE-A8ZQ	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	914:918	Mutation altering degron motif	0.6752
p.P914S	DO51288	SKCM	ICGC	LTPLSS	DEG_SCF_FBW7_1	912:917	Mutation altering degron motif	0.6752
p.P914S	DO51288	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	914:918	Mutation altering degron motif	0.6752
p.P980L	TCGA-XF-A8HG	BLCA	TCGA	PPFY	ITCH	981:984	Mutation rewiring degron network	0.3056
p.P980L	DO49802	BLCA	ICGC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.3056
p.P980L	DO222837	MELA	ICGC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.3056
p.P1145H	DO224598	BRCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.3056
p.P1145H	DO1010	BRCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.3056
p.P1152L	DO49880	CESC	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.3056
p.P1152L	DO232761	PBCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.3056
p.H1158Q	DO7436	CLLE	ICGC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1389
p.T913I	DO227979	COCA	ICGC	LTPLSS	DEG_SCF_FBW7_1	912:917	Mutation altering degron motif	0.7078
p.Q1331R	DO229010	COCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.Q1331R	DO229013	COCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.Q1331R	DO229005	COCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.Q1331R	DO230554	LUSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.Q1331R	DO230993	LUSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.Q1331R	DO27775	MALY	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.P1321S	DO228696	EOPC	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation altering degron motif	0.5641
p.T1310M	DO234459	ESAD	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1389
p.F932L	DO229027	LICA	ICGC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.2222
p.A927E	DO229034	LICA	ICGC	PPAY	ITCH	925:928	Mutation altering degron motif	0.659
p.D1333V	DO50974	LICA	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.0556
p.P982S	DO50970	LICA	ICGC	PPFY	ITCH	981:984	Mutation altering degron motif	0.6752
p.E1313K	DO222702	MELA	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.2222
p.Q1331H	DO232761	PBCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.1111
p.R1332K	DO41500	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.0833
p.P1322A	SIDM01037	Breast Carcinoma	GDSC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation altering degron motif	0.6392
p.P1322A	SIDM01134	Small Cell Lung Carcinoma	GDSC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation altering degron motif	0.6392
p.S973R	SIDM00461	Acute Myeloid Leukemia	GDSC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.S973R	ACH-000065	Leukemia	CCLE	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.S973R	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.P1155L	SIDM00933	Breast Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.2222
p.P1155L	ACH-000856	Breast Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.2222
p.P1155L	CAL-51	breast	COSMIC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.2222
p.R935H	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1389
p.R935H	HCE-4	oesophagus	COSMIC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.1389
p.P930T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.2778
p.P930T	ACH-000945	Lung Cancer	CCLE	PPAY	ITCH	925:928	Mutation rewiring degron network	0.2778
p.P930T	NCI-H650	lung	COSMIC	PPAY	ITCH	925:928	Mutation rewiring degron network	0.2778
p.A1157E	SIDM01088	Endometrial Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1667
p.A1157E	ACH-000965	Endometrial/Uterine Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1667
p.A1157E	RL95-2	endometrium	COSMIC	VLPYPE	LIG_APCC_ABBA_1	1146:1151	Mutation rewiring degron network	0.1667
p.S990R	SIDM01063	Acute Myeloid Leukemia	GDSC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1667
p.S990R	ACH-000190	Unknown	CCLE	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1667
p.S990R	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	981:984	Mutation rewiring degron network	0.1667
p.L1315F	SIDM01064	Hodgkin's Lymphoma	GDSC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.2778
p.L1315F	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation rewiring degron network	0.2778
p.T1329K	ACH-000865	Esophageal Cancer	CCLE	PETPPPT	DEG_SCF_FBW7_1	1317:1323	Mutation substituting flanking lysine	0.2778
p.S917F	ACH-002024	Colon/Colorectal Cancer	CCLE	LTPLSS	DEG_SCF_FBW7_1	912:917	Mutation altering degron motif	0.9093
p.S917F	ACH-002024	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	914:918	Mutation altering degron motif	0.9093

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGSF9B

UniProt ID: Q9UPX0

Entrez ID: 22997

Protein name: Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGSF9B in