DegronMD

Uniprot ID: Q9UPX0

Source protein: Protein turtle homolog B

Source gene: IGSF9B

Class: DEG_SCF_FBW7_1

Location: 1317:1323

E3 ligase: FBXW7

DEGRON score: 0.5981

ASA_SCORE: 94.3

COIL: 0.9634

CONS_SCORE: 0.3541

DSS_SCORE: 0.8639

HELIX: 0.0084

FCONS_SCORE: 0.9847

RIG_SCORE: 0.5835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1309K	TCGA-21-1079	LUSC	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.R1309K	DO26846	LUSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.G1311V	TCGA-78-8662	LUAD	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.1667
p.G1311V	DO45346	LUAD	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1667
p.T1323M	TCGA-AA-3530	COAD	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.7423
p.T1323M	DO8970	COAD	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.7423
p.G1311R	TCGA-BA-A6DA	HNSC	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.1667
p.G1311R	DO44448	HNSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1667
p.R1316Q	TCGA-EO-A3B0	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.3056
p.R1316Q	DO219773	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.3056
p.Q1331R	DO229010	COCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.Q1331R	DO229013	COCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.Q1331R	DO229005	COCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.Q1331R	DO230554	LUSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.Q1331R	DO230993	LUSC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.Q1331R	DO27775	MALY	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.P1321S	DO228696	EOPC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.5641
p.T1310M	DO234459	ESAD	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1389
p.D1333V	DO50974	LICA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.0556
p.E1313K	DO222702	MELA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.2222
p.Q1331H	DO232761	PBCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.R1332K	DO41500	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.0833
p.P1322A	SIDM01037	Breast Carcinoma	GDSC	PETPPPT	DEG_SCF_FBW7_1	0.6392
p.P1322A	SIDM01134	Small Cell Lung Carcinoma	GDSC	PETPPPT	DEG_SCF_FBW7_1	0.6392
p.L1315F	SIDM01064	Hodgkin's Lymphoma	GDSC	PETPPPT	DEG_SCF_FBW7_1	0.2778
p.L1315F	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PETPPPT	DEG_SCF_FBW7_1	0.2778
p.T1329K	ACH-000865	Esophageal Cancer	CCLE	PETPPPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	847:853	PETPPPT	FBXW7	0.9927	More...
Q9UPX0	Protein turtle homolog B	DEG_SCF_FBW7_1	1317:1323	PETPPPT	FBXW7	0.5981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETPPPT

Degron related mutations and impact score

Drug responses associated with IGSF9B mutations

All proteins holding degron of PETPPPT