DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 847:853

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 106.0143

COIL: 0.9793

CONS_SCORE: 0.3508

DSS_SCORE: 0.8088

HELIX: 0.0083

FCONS_SCORE: 1.112

RIG_SCORE: 0.5202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K840N	TCGA-AX-A05Z	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.25
p.K840N	DO40884	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.25
p.P839H	TCGA-DF-A2KN	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.P839H	DO223282	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.1111
p.E856D	TCGA-EY-A215	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	0.25
p.E856D	DO233729	GACA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.25
p.E856D	DO42665	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.25
p.K841R	DO229377	BTCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	0.6111
p.T837A	CCK-81	large_intestine	COSMIC	PETPPPT	DEG_SCF_FBW7_1	0.0556
p.K843M	OC-314	ovary	COSMIC	PETPPPT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons