DegronMD

Uniprot ID: Q9UPX0

Source protein: Protein turtle homolog B

Source gene: IGSF9B

Class: LIG_APCC_ABBA_1

Location: 1146:1151

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 80.9833

COIL: 0.929

CONS_SCORE: 0.4105

DSS_SCORE: 0.6512

HELIX: 0.0063

FCONS_SCORE: 1.0704

RIG_SCORE: 0.6843

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1151K	TCGA-CG-4460	STAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.7022
p.E1151K	DO38427	STAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.7022
p.P1150S	TCGA-FR-A8YC	SKCM	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.5641
p.P1150S	DO50301	SKCM	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.5641
p.P1145H	DO224598	BRCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.P1145H	DO1010	BRCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.P1152L	DO49880	CESC	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.P1152L	DO232761	PBCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.M1142V	TCGA-55-8089	LUAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.M1142V	DO23690	LUAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.P1155L	SIDM00933	Breast Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.P1155L	ACH-000856	Breast Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.P1155L	CAL-51	breast	COSMIC	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.G1141V	TCGA-AJ-A3EK	UCEC	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1141V	DO41584	UCEC	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1141V	SIDM01343	Gastric Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1141V	ACH-000764	Gastric Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1156R	TCGA-IN-A7NU	STAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1156R	DO51746	STAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.Q1140R	TCGA-BG-A222	UCEC	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.Q1140R	DO42977	UCEC	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.A1157E	SIDM01088	Endometrial Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.A1157E	ACH-000965	Endometrial/Uterine Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.A1157E	RL95-2	endometrium	COSMIC	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.H1158Q	DO7436	CLLE	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1389

Showing 1 to 25 of 31 entries

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPX0	Protein turtle homolog B	LIG_APCC_ABBA_1	1146:1151	VLPYPE	APC,CDC20,FZR1	0.9963	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons