DegronMD

Uniprot ID: Q9UPX0

Source protein: Protein turtle homolog B

Source gene: IGSF9B

Class: LIG_APCC_ABBA_1

Location: 1146:1151

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 80.9833

COIL: 0.929

CONS_SCORE: 0.4105

DSS_SCORE: 0.6512

HELIX: 0.0063

FCONS_SCORE: 1.0704

RIG_SCORE: 0.6843

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1159S	TCGA-55-7907	LUAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.1111
p.G1159S	DO25396	LUAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1111
p.M1142V	TCGA-55-8089	LUAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.M1142V	DO23690	LUAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.G1141V	TCGA-AJ-A3EK	UCEC	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1141V	DO41584	UCEC	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1141V	SIDM01343	Gastric Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1141V	ACH-000764	Gastric Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.Q1140R	TCGA-BG-A222	UCEC	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.Q1140R	DO42977	UCEC	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.E1151K	TCGA-CG-4460	STAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.7022
p.E1151K	DO38427	STAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.7022
p.R1136Q	TCGA-CM-6165	COAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.0556
p.R1136Q	DO9900	COAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.0556
p.P1150S	TCGA-FR-A8YC	SKCM	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.5641
p.P1150S	DO50301	SKCM	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.5641
p.G1160S	TCGA-IB-7651	PAAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.0833
p.G1160S	DO46657	PAAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.0833
p.G1156R	TCGA-IN-A7NU	STAD	TCGA	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.G1156R	DO51746	STAD	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1944
p.P1145H	DO224598	BRCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.P1145H	DO1010	BRCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.P1152L	DO49880	CESC	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.P1152L	DO232761	PBCA	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.3056
p.H1158Q	DO7436	CLLE	ICGC	VLPYPE	LIG_APCC_ABBA_1	0.1389
p.P1155L	SIDM00933	Breast Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.P1155L	ACH-000856	Breast Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.P1155L	CAL-51	breast	COSMIC	VLPYPE	LIG_APCC_ABBA_1	0.2222
p.A1157E	SIDM01088	Endometrial Carcinoma	GDSC	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.A1157E	ACH-000965	Endometrial/Uterine Cancer	CCLE	VLPYPE	LIG_APCC_ABBA_1	0.1667
p.A1157E	RL95-2	endometrium	COSMIC	VLPYPE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLPYPE

Degron related mutations and impact score

Drug responses associated with IGSF9B mutations

All proteins holding degron of VLPYPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPX0	Protein turtle homolog B	LIG_APCC_ABBA_1	1146:1151	VLPYPE	APC,CDC20,FZR1	0.9963	More...