DegronMD

Uniprot ID: Q9UPX0

Source protein: Protein turtle homolog B

Source gene: IGSF9B

Class: DEG_SCF_FBW7_1

Location: 912:917

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 80.55

COIL: 0.9008

CONS_SCORE: 0.2823

DSS_SCORE: 0.5513

HELIX: 0.0597

FCONS_SCORE: 0.8071

RIG_SCORE: 0.645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L912R	TCGA-VQ-A8DZ	STAD	TCGA	LTPLSS	DEG_SCF_FBW7_1	0.8428
p.L912R	DO51755	STAD	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.8428
p.P914S	TCGA-WE-A8ZQ	SKCM	TCGA	LTPLSS	DEG_SCF_FBW7_1	0.6752
p.P914S	DO51288	SKCM	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.6752
p.T913I	DO227979	COCA	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.7078
p.S917F	ACH-002024	Colon/Colorectal Cancer	CCLE	LTPLSS	DEG_SCF_FBW7_1	0.9093

DegronMD: protein-targeted degradation, mutation and drug response to degrons