DegronMD

Uniprot ID: Q9H2A3

Source protein: Neurogenin-2

Source gene: NEUROG2

Class: DEG_SCF_FBW7_1

Location: 30:35

E3 ligase: FBXW7

DEGRON score: 0.977

ASA_SCORE: 76.1833

COIL: 0.8968

CONS_SCORE: 0.4673

DSS_SCORE: 0.646

HELIX: 0.0827

FCONS_SCORE: 0.9978

RIG_SCORE: 0.6657

Degron related mutations and impact score

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P32L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.7582
p.P32L	ACH-000924	Lung Cancer	CCLE	LTPLSS	DEG_SCF_FBW7_1	0.7582
p.P32L	NCI-H2172	lung	COSMIC	LTPLSS	DEG_SCF_FBW7_1	0.7582
p.A29V	DO229005	COCA	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	DO229047	LICA	ICGC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00608	Plasma Cell Myeloma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00570	Gastric Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00194	Colorectal Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00584	Osteosarcoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00304	Ovarian Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00600	Thyroid Gland Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00157	Neuroblastoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00544	Neuroblastoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00362	Burkitt's Lymphoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00296	Small Cell Lung Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00581	Glioblastoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00571	Pancreatic Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM01194	Hepatocellular Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00060	Ovarian Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00238	Ovarian Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00282	Colorectal Carcinoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056
p.A29V	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLSS	DEG_SCF_FBW7_1	0.3056

Showing 1 to 25 of 65 entries

Previous1 2 3Next

Drug responses associated with NEUROG2 mutations

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

All proteins holding degron of LTPLSS

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2A3	Neurogenin-2	DEG_SCF_FBW7_1	30:35	LTPLSS	FBXW7	0.977	More...
Q9UPX0	Protein turtle homolog B	DEG_SCF_FBW7_1	912:917	LTPLSS	FBXW7	0.9978	More...
Q6ZP01	RNA-binding protein 44	DEG_SCF_FBW7_1	127:132	LTPLSS	FBXW7	0.87	More...

Showing 1 to 3 of 3 entries

Previous1Next

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLSS

Degron related mutations and impact score

Drug responses associated with NEUROG2 mutations

All proteins holding degron of LTPLSS