DegronMD

Uniprot ID: Q9UPX0

Source protein: Protein turtle homolog B

Source gene: IGSF9B

Class: ITCH

Location: 981:984

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9332

ASA_SCORE: 60.8

COIL: 0.81

CONS_SCORE: 0.4101

DSS_SCORE: 0.5267

HELIX: 0.0298

FCONS_SCORE: 1.0959

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S990I	TCGA-37-4130	LUSC	TCGA	PPFY	ITCH	0.1667
p.S990I	DO26490	LUSC	ICGC	PPFY	ITCH	0.1667
p.S973C	TCGA-85-A4JB	LUSC	TCGA	PPFY	ITCH	0.1111
p.S973C	DO45517	LUSC	ICGC	PPFY	ITCH	0.1111
p.P982L	TCGA-AA-3662	COAD	TCGA	PPFY	ITCH	0.7582
p.P982L	DO6958	CLLE	ICGC	PPFY	ITCH	0.7582
p.P982L	DO8336	COAD	ICGC	PPFY	ITCH	0.7582
p.P982L	DO233705	GACA	ICGC	PPFY	ITCH	0.7582
p.P982T	TCGA-D3-A3CF	SKCM	TCGA	PPFY	ITCH	0.7031
p.P982T	DO37675	SKCM	ICGC	PPFY	ITCH	0.7031
p.E977K	TCGA-EO-A22U	UCEC	TCGA	PPFY	ITCH	0.2222
p.E977K	DO43755	UCEC	ICGC	PPFY	ITCH	0.2222
p.V985M	TCGA-KQ-A41N	BLCA	TCGA	PPFY	ITCH	0.3056
p.V985M	DO223588	BLCA	ICGC	PPFY	ITCH	0.3056
p.P980L	TCGA-XF-A8HG	BLCA	TCGA	PPFY	ITCH	0.3056
p.P980L	DO49802	BLCA	ICGC	PPFY	ITCH	0.3056
p.P980L	DO222837	MELA	ICGC	PPFY	ITCH	0.3056
p.P982S	DO50970	LICA	ICGC	PPFY	ITCH	0.6752
p.S973R	SIDM00461	Acute Myeloid Leukemia	GDSC	PPFY	ITCH	0.1111
p.S973R	ACH-000065	Leukemia	CCLE	PPFY	ITCH	0.1111
p.S973R	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.1111
p.S990R	SIDM01063	Acute Myeloid Leukemia	GDSC	PPFY	ITCH	0.1667
p.S990R	ACH-000190	Unknown	CCLE	PPFY	ITCH	0.1667
p.S990R	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17643	5,6-dihydroxyindole-2-carboxylic acid oxidase	ITCH	345:348	PPFY	ITCH,NEDD4	0.695	More...
P18583	Protein SON	ITCH	2136:2139	PPFY	ITCH,NEDD4	0.9982	More...
P78563	Double-stranded RNA-specific editase 1	ITCH	188:191	PPFY	ITCH,NEDD4	0.9978	More...
Q16644	MAP kinase-activated protein kinase 3	ITCH	240:243	PPFY	ITCH,NEDD4	0.6619	More...
Q5TBA9	Protein furry homolog	ITCH	1514:1517	PPFY	ITCH,NEDD4	0.7858	More...
Q5VTD9	Zinc finger protein Gfi-1b	ITCH	99:102	PPFY	ITCH,NEDD4	0.9889	More...
Q5VYJ5	MAM and LDL-receptor class A domain-containing protein 1	ITCH	103:106	PPFY	ITCH,NEDD4	0.6037	More...
Q6ZN30	Zinc finger protein basonuclin-2	ITCH	570:573	PPFY	ITCH,NEDD4	0.7924	More...
Q8IW41	MAP kinase-activated protein kinase 5	ITCH	239:242	PPFY	ITCH,NEDD4	0.887	More...
Q9UPX0	Protein turtle homolog B	ITCH	981:984	PPFY	ITCH,NEDD4	0.9332	More...
Q6ZTI6	Refilin-A	ITCH	38:41	PPFY	ITCH,NEDD4	0.9921	More...
Q7Z2T5	TRMT1-like protein	ITCH	632:635	PPFY	ITCH,NEDD4	0.8239	More...
A4D0V7	Cadherin-like and PC-esterase domain-containing protein 1	ITCH	104:107	PPFY	ITCH,NEDD4	0.9116	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	4949:4952	PPFY	ITCH,NEDD4	0.8101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons