DegronMD - Q16644(MAPKAPK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K367N	TCGA-55-7725	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation substituting flanking lysine	0.3611
p.K367N	DO24636	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation substituting flanking lysine	0.3611
p.G238D	TCGA-BR-7703	STAD	TCGA	PPFY	ITCH	240:243	Mutation rewiring degron network	0.2778
p.G238D	DO38232	STAD	ICGC	PPFY	ITCH	240:243	Mutation rewiring degron network	0.2778
p.S251F	TCGA-CN-6998	HNSC	TCGA	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.5556
p.S251F	TCGA-EE-A29D	SKCM	TCGA	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.5556
p.S251F	DO15519	HNSC	ICGC	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.5556
p.S251F	DO38123	SKCM	ICGC	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.5556
p.S307L	TCGA-FW-A3R5	SKCM	TCGA	VPQTPLHT	DEG_SCF_FBW7_1	310:317	Mutation blocking phosphorylation signal	0.6944
p.S307L	DO37406	SKCM	ICGC	VPQTPLHT	DEG_SCF_FBW7_1	310:317	Mutation blocking phosphorylation signal	0.6944
p.G371D	TCGA-G4-6628	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.6087
p.G371D	DO10132	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.6087
p.A318T	TCGA-IR-A3LA	CESC	TCGA	VPQTPLHT	DEG_SCF_FBW7_1	310:317	Mutation rewiring degron network	0.3056
p.A318T	DO44377	CESC	ICGC	VPQTPLHT	DEG_SCF_FBW7_1	310:317	Mutation rewiring degron network	0.3056
p.S373Y	TCGA-VS-A8EL	CESC	TCGA	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.8231
p.S373Y	DO51624	CESC	ICGC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.8231
p.T246M	DO233898	GACA	ICGC	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.6944
p.T246M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.6944
p.T246M	ACH-000953	Leukemia	CCLE	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.6944
p.T246M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	240:243	Mutation blocking phosphorylation signal	0.6944
p.P252Q	DO231049	LUSC	ICGC	PPFY	ITCH	240:243	Mutation rewiring degron network	0.0833
p.C379W	DO229229	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1944
p.S373F	SIDM00007	Other Solid Cancers	GDSC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.9093
p.S373F	ACH-001550	Skin Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.9093
p.S373F	MCC13	skin	COSMIC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.9093
p.R360W	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.R360W	ACH-000062	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.R360W	RERF-LC-MS	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.R319Q	ACH-000950	Colon/Colorectal Cancer	CCLE	VPQTPLHT	DEG_SCF_FBW7_1	310:317	Mutation rewiring degron network	0.2778
p.R319Q	ACH-000995	Leukemia	CCLE	VPQTPLHT	DEG_SCF_FBW7_1	310:317	Mutation rewiring degron network	0.2778

Kaplan plot for MAPKAPK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAPKAPK3

UniProt ID: Q16644

Entrez ID: 7867

Protein name: MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAPKAPK3 in