DegronMD

Uniprot ID: Q16644

Source protein: MAP kinase-activated protein kinase 3

Source gene: MAPKAPK3

Class: DEG_SCF_FBW7_1

Location: 310:317

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 75.1625

COIL: 0.899

CONS_SCORE: 0.7397

DSS_SCORE: 0.4066

HELIX: 0.0696

FCONS_SCORE: 1.0811

RIG_SCORE: 0.7614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S307L	TCGA-FW-A3R5	SKCM	TCGA	VPQTPLHT	DEG_SCF_FBW7_1	0.6944
p.S307L	DO37406	SKCM	ICGC	VPQTPLHT	DEG_SCF_FBW7_1	0.6944
p.A318T	TCGA-IR-A3LA	CESC	TCGA	VPQTPLHT	DEG_SCF_FBW7_1	0.3056
p.A318T	DO44377	CESC	ICGC	VPQTPLHT	DEG_SCF_FBW7_1	0.3056
p.R319Q	ACH-000950	Colon/Colorectal Cancer	CCLE	VPQTPLHT	DEG_SCF_FBW7_1	0.2778
p.R319Q	ACH-000995	Leukemia	CCLE	VPQTPLHT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49137	MAP kinase-activated protein kinase 2	DEG_SCF_FBW7_1	331:338	VPQTPLHT	FBXW7	0.9981	More...
Q16644	MAP kinase-activated protein kinase 3	DEG_SCF_FBW7_1	310:317	VPQTPLHT	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons