DegronMD

Uniprot ID: P49137

Source protein: MAP kinase-activated protein kinase 2

Source gene: MAPKAPK2

Class: DEG_SCF_FBW7_1

Location: 331:338

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 71

COIL: 0.9213

CONS_SCORE: 0.7814

DSS_SCORE: 0.4976

HELIX: 0.0481

FCONS_SCORE: 1.4243

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H322Y	TCGA-AP-A1DK	UCEC	TCGA	VPQTPLHT	DEG_SCF_FBW7_1	0.0833
p.H322Y	DO42033	UCEC	ICGC	VPQTPLHT	DEG_SCF_FBW7_1	0.0833
p.H322Y	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VPQTPLHT	DEG_SCF_FBW7_1	0.0833
p.H322Y	ACH-000769	Lung Cancer	CCLE	VPQTPLHT	DEG_SCF_FBW7_1	0.0833
p.H322Y	LK-2	lung	COSMIC	VPQTPLHT	DEG_SCF_FBW7_1	0.0833
p.P332H	TCGA-DA-A1IB	SKCM	TCGA	VPQTPLHT	DEG_SCF_FBW7_1	0.6583
p.P332H	DO38033	SKCM	ICGC	VPQTPLHT	DEG_SCF_FBW7_1	0.6583
p.S339N	TCGA-DF-A2KU	UCEC	TCGA	VPQTPLHT	DEG_SCF_FBW7_1	0.75
p.S339N	DO223286	UCEC	ICGC	VPQTPLHT	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49137	MAP kinase-activated protein kinase 2	DEG_SCF_FBW7_1	331:338	VPQTPLHT	FBXW7	0.9981	More...
Q16644	MAP kinase-activated protein kinase 3	DEG_SCF_FBW7_1	310:317	VPQTPLHT	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons