DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPFY
Uniprot ID:
Q7Z2T5
Source protein:
TRMT1-like protein
Source gene:
TRMT1L
Class:
ITCH
Location:
632:635
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.8239
ASA_SCORE:
38.5
COIL:
0.7448
CONS_SCORE:
0.7867
DSS_SCORE:
0.3857
HELIX:
0.0555
FCONS_SCORE:
1.2496
RIG_SCORE:
0.7612
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P632H
TCGA-AJ-A3EK
UCEC
TCGA
PPFY
ITCH
0.7694
p.P632H
DO41584
UCEC
ICGC
PPFY
ITCH
0.7694
p.N637K
DO229032
LICA
ICGC
PPFY
ITCH
0.2778
Drug responses associated with TRMT1L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPFY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P17643
5,6-dihydroxyindole-2-carboxylic acid oxidase
ITCH
345:348
PPFY
ITCH,NEDD4
0.695
More...
P18583
Protein SON
ITCH
2136:2139
PPFY
ITCH,NEDD4
0.9982
More...
P78563
Double-stranded RNA-specific editase 1
ITCH
188:191
PPFY
ITCH,NEDD4
0.9978
More...
Q16644
MAP kinase-activated protein kinase 3
ITCH
240:243
PPFY
ITCH,NEDD4
0.6619
More...
Q5TBA9
Protein furry homolog
ITCH
1514:1517
PPFY
ITCH,NEDD4
0.7858
More...
Q5VTD9
Zinc finger protein Gfi-1b
ITCH
99:102
PPFY
ITCH,NEDD4
0.9889
More...
Q5VYJ5
MAM and LDL-receptor class A domain-containing protein 1
ITCH
103:106
PPFY
ITCH,NEDD4
0.6037
More...
Q6ZN30
Zinc finger protein basonuclin-2
ITCH
570:573
PPFY
ITCH,NEDD4
0.7924
More...
Q8IW41
MAP kinase-activated protein kinase 5
ITCH
239:242
PPFY
ITCH,NEDD4
0.887
More...
Q9UPX0
Protein turtle homolog B
ITCH
981:984
PPFY
ITCH,NEDD4
0.9332
More...
Q6ZTI6
Refilin-A
ITCH
38:41
PPFY
ITCH,NEDD4
0.9921
More...
Q7Z2T5
TRMT1-like protein
ITCH
632:635
PPFY
ITCH,NEDD4
0.8239
More...
A4D0V7
Cadherin-like and PC-esterase domain-containing protein 1
ITCH
104:107
PPFY
ITCH,NEDD4
0.9116
More...
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
ITCH
4949:4952
PPFY
ITCH,NEDD4
0.8101
More...