DegronMD - Q5VTD9(GFI1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D97N	TCGA-26-5133	GBM	TCGA	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.D97N	DO12580	GBM	ICGC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.D97N	SIDM00930	Osteosarcoma	GDSC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.D97N	CAL-72	bone	COSMIC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.D97Y	TCGA-37-5819	LUSC	TCGA	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.D97Y	TCGA-B0-5695	KIRC	TCGA	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.D97Y	DO17054	KIRC	ICGC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.D97Y	DO26479	LUSC	ICGC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.F101L	TCGA-AX-A2HC	UCEC	TCGA	PPFY	ITCH	99:102	Mutation altering degron motif	0.587
p.F101L	DO41572	UCEC	ICGC	PPFY	ITCH	99:102	Mutation altering degron motif	0.587
p.K230R	TCGA-BR-8589	STAD	TCGA	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation substituting flanking lysine	0.1944
p.K230R	DO47813	STAD	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation substituting flanking lysine	0.1944
p.T245R	TCGA-DA-A1I8	SKCM	TCGA	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation blocking phosphorylation signal	0.75
p.T245R	DO37424	SKCM	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation blocking phosphorylation signal	0.75
p.P104H	TCGA-EO-A3B0	UCEC	TCGA	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.P104H	DO219773	UCEC	ICGC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.2778
p.S232L	TCGA-SY-A9G5	BLCA	TCGA	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1389
p.S232L	DO51906	BLCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1389
p.D92N	TCGA-W3-AA1V	SKCM	TCGA	PPFY	ITCH	99:102	Mutation rewiring degron network	0.1389
p.D92N	DO51276	SKCM	ICGC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.1389
p.P247S	TCGA-ZF-A9RN	BLCA	TCGA	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.25
p.P247S	DO219081	BLCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.25
p.F252L	DO8898	COAD	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1111
p.C253Y	DO227987	COCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.0833
p.L240F	DO222501	COCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation altering degron motif	0.587
p.L111F	DO229034	LICA	ICGC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.0833
p.G254S	DO232761	PBCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.0556
p.S98L	SIDM00418	Thyroid Gland Carcinoma	GDSC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.3056
p.S98L	SIDM00792	Small Cell Lung Carcinoma	GDSC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.3056
p.G91W	SIDM00694	Other Solid Cancers	GDSC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.1111
p.G91W	ACH-000538	Gastric Cancer	CCLE	PPFY	ITCH	99:102	Mutation rewiring degron network	0.1111
p.G91W	HUTU-80	small intestine	COSMIC	PPFY	ITCH	99:102	Mutation rewiring degron network	0.1111
p.R231C	SIDM00217	Colorectal Carcinoma	GDSC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1111
p.R231C	ACH-000999	Colon/Colorectal Cancer	CCLE	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1111
p.R231C	SNU-1040	large intestine	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1111
p.L240I	SIDM01611	Endometrial Carcinoma	GDSC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation altering degron motif	0.6063
p.L240I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation altering degron motif	0.6063
p.S93C	ACH-001864	Bile Duct Cancer	CCLE	PPFY	ITCH	99:102	Mutation rewiring degron network	0.1667
p.H248Y	MCC13	skin	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.2222
p.P243L	JHH-7	liver	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation altering degron motif	0.7582
p.P234T	ME-1	haematopoietic and lymphoid tissue	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1944
p.G248D	HCT-116	large intestine	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.2222
p.S243Y	NCI-H2342	lung	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation altering degron motif	0.712
p.P233L	JHH-7	liver	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation blocking phosphorylation signal	0.6111
p.K231N	Becker	central nervous system	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.1111
p.R253C	SNU-1040	large intestine	COSMIC	LLIHSD	LIG_APCC_ABBA_1	239:244	Mutation rewiring degron network	0.0833

Kaplan plot for GFI1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GFI1B

UniProt ID: Q5VTD9

Entrez ID: 8328

Protein name: Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GFI1B in