DegronMD

Uniprot ID: Q5VTD9

Source protein: Zinc finger protein Gfi-1b

Source gene: GFI1B

Class: LIG_APCC_ABBA_1

Location: 239:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8913

ASA_SCORE: 64.4167

COIL: 0.5922

CONS_SCORE: 0.9918

DSS_SCORE: 0.266

HELIX: 0.0158

FCONS_SCORE: 1.0309

RIG_SCORE: 0.7784

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K230R	TCGA-BR-8589	STAD	TCGA	LLIHSD	LIG_APCC_ABBA_1	0.1944
p.K230R	DO47813	STAD	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.1944
p.T245R	TCGA-DA-A1I8	SKCM	TCGA	LLIHSD	LIG_APCC_ABBA_1	0.75
p.T245R	DO37424	SKCM	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.75
p.S232L	TCGA-SY-A9G5	BLCA	TCGA	LLIHSD	LIG_APCC_ABBA_1	0.1389
p.S232L	DO51906	BLCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.1389
p.P247S	TCGA-ZF-A9RN	BLCA	TCGA	LLIHSD	LIG_APCC_ABBA_1	0.25
p.P247S	DO219081	BLCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.25
p.F252L	DO8898	COAD	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.1111
p.C253Y	DO227987	COCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.0833
p.L240F	DO222501	COCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.587
p.G254S	DO232761	PBCA	ICGC	LLIHSD	LIG_APCC_ABBA_1	0.0556
p.R231C	SIDM00217	Colorectal Carcinoma	GDSC	LLIHSD	LIG_APCC_ABBA_1	0.1111
p.R231C	ACH-000999	Colon/Colorectal Cancer	CCLE	LLIHSD	LIG_APCC_ABBA_1	0.1111
p.R231C	SNU-1040	large_intestine	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.1111
p.L240I	SIDM01611	Endometrial Carcinoma	GDSC	LLIHSD	LIG_APCC_ABBA_1	0.6063
p.L240I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLIHSD	LIG_APCC_ABBA_1	0.6063
p.H248Y	MCC13	skin	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.2222
p.P243L	JHH-7	liver	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.7582
p.P234T	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.1944
p.G248D	HCT-116	large_intestine	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.2222
p.S243Y	NCI-H2342	lung	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.712
p.P233L	JHH-7	liver	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.6111
p.K231N	Becker	central_nervous_system	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.1111
p.R253C	SNU-1040	large_intestine	COSMIC	LLIHSD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VTD9	Zinc finger protein Gfi-1b	LIG_APCC_ABBA_1	239:244	LLIHSD	APC,CDC20,FZR1	0.8913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLIHSD

Degron related mutations and impact score

Drug responses associated with GFI1B mutations

All proteins holding degron of LLIHSD