DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPFY
Uniprot ID:
Q5VTD9
Source protein:
Zinc finger protein Gfi-1b
Source gene:
GFI1B
Class:
ITCH
Location:
99:102
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9889
ASA_SCORE:
97.925
COIL:
0.9265
CONS_SCORE:
0.5734
DSS_SCORE:
0.4836
HELIX:
0.0295
FCONS_SCORE:
1.2902
RIG_SCORE:
0.6633
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D97N
TCGA-26-5133
GBM
TCGA
PPFY
ITCH
0.2778
p.D97N
DO12580
GBM
ICGC
PPFY
ITCH
0.2778
p.D97N
SIDM00930
Osteosarcoma
GDSC
PPFY
ITCH
0.2778
p.D97N
CAL-72
bone
COSMIC
PPFY
ITCH
0.2778
p.D97Y
TCGA-37-5819
LUSC
TCGA
PPFY
ITCH
0.2778
p.D97Y
TCGA-B0-5695
KIRC
TCGA
PPFY
ITCH
0.2778
p.D97Y
DO17054
KIRC
ICGC
PPFY
ITCH
0.2778
p.D97Y
DO26479
LUSC
ICGC
PPFY
ITCH
0.2778
p.F101L
TCGA-AX-A2HC
UCEC
TCGA
PPFY
ITCH
0.587
p.F101L
DO41572
UCEC
ICGC
PPFY
ITCH
0.587
p.P104H
TCGA-EO-A3B0
UCEC
TCGA
PPFY
ITCH
0.2778
p.P104H
DO219773
UCEC
ICGC
PPFY
ITCH
0.2778
p.D92N
TCGA-W3-AA1V
SKCM
TCGA
PPFY
ITCH
0.1389
p.D92N
DO51276
SKCM
ICGC
PPFY
ITCH
0.1389
p.L111F
DO229034
LICA
ICGC
PPFY
ITCH
0.0833
p.S98L
SIDM00418
Thyroid Gland Carcinoma
GDSC
PPFY
ITCH
0.3056
p.S98L
SIDM00792
Small Cell Lung Carcinoma
GDSC
PPFY
ITCH
0.3056
p.G91W
SIDM00694
Other Solid Cancers
GDSC
PPFY
ITCH
0.1111
p.G91W
ACH-000538
Gastric Cancer
CCLE
PPFY
ITCH
0.1111
p.G91W
HUTU-80
small_intestine
COSMIC
PPFY
ITCH
0.1111
p.S93C
ACH-001864
Bile Duct Cancer
CCLE
PPFY
ITCH
0.1667
Drug responses associated with GFI1B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPFY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P17643
5,6-dihydroxyindole-2-carboxylic acid oxidase
ITCH
345:348
PPFY
ITCH,NEDD4
0.695
More...
P18583
Protein SON
ITCH
2136:2139
PPFY
ITCH,NEDD4
0.9982
More...
P78563
Double-stranded RNA-specific editase 1
ITCH
188:191
PPFY
ITCH,NEDD4
0.9978
More...
Q16644
MAP kinase-activated protein kinase 3
ITCH
240:243
PPFY
ITCH,NEDD4
0.6619
More...
Q5TBA9
Protein furry homolog
ITCH
1514:1517
PPFY
ITCH,NEDD4
0.7858
More...
Q5VTD9
Zinc finger protein Gfi-1b
ITCH
99:102
PPFY
ITCH,NEDD4
0.9889
More...
Q5VYJ5
MAM and LDL-receptor class A domain-containing protein 1
ITCH
103:106
PPFY
ITCH,NEDD4
0.6037
More...
Q6ZN30
Zinc finger protein basonuclin-2
ITCH
570:573
PPFY
ITCH,NEDD4
0.7924
More...
Q8IW41
MAP kinase-activated protein kinase 5
ITCH
239:242
PPFY
ITCH,NEDD4
0.887
More...
Q9UPX0
Protein turtle homolog B
ITCH
981:984
PPFY
ITCH,NEDD4
0.9332
More...
Q6ZTI6
Refilin-A
ITCH
38:41
PPFY
ITCH,NEDD4
0.9921
More...
Q7Z2T5
TRMT1-like protein
ITCH
632:635
PPFY
ITCH,NEDD4
0.8239
More...
A4D0V7
Cadherin-like and PC-esterase domain-containing protein 1
ITCH
104:107
PPFY
ITCH,NEDD4
0.9116
More...
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
ITCH
4949:4952
PPFY
ITCH,NEDD4
0.8101
More...