DegronMD - Q6ZN30(BNC2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P382R	TCGA-13-0920	OV	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.3056
p.S575R	TCGA-17-Z028	LUAD	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2778
p.S575R	TCGA-AA-3975	COAD	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2778
p.S575R	TCGA-CD-8524	STAD	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2778
p.S575R	TCGA-CD-A48C	STAD	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2778
p.S575R	TCGA-D7-6525	STAD	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2778
p.S575R	SIDM01296	Esophageal Carcinoma	GDSC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2778
p.T391N	TCGA-60-2714	LUSC	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.5944
p.H621L	TCGA-86-8073	LUAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.1667
p.N392K	TCGA-AJ-A3EK	UCEC	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.3056
p.P623S	TCGA-AP-A059	UCEC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2222
p.P623S	DO229039	LICA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2222
p.T391A	TCGA-AX-A0J1	UCEC	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.6028
p.S575I	TCGA-BR-8370	STAD	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2778
p.K630N	TCGA-CA-6718	COAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.5806
p.K630M	TCGA-CV-5442	HNSC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.6951
p.A650V	TCGA-D1-A17Q	UCEC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0556
p.E581K	TCGA-D3-A2JF	SKCM	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.1111
p.P639S	TCGA-EE-A3AF	SKCM	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.5641
p.R574G	TCGA-EL-A3ZR	THCA	TCGA	PPFY	ITCH	570:573	Mutation rewiring degron network	0.3056
p.A650T	TCGA-EO-A22U	UCEC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0556
p.H621Y	TCGA-G3-A25T	LIHC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.1667
p.T374A	TCGA-IB-7651	PAAD	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.M618K	TCGA-PK-A5HB	ACC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0833
p.M618K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0833
p.M618K	ACH-000916	Lung Cancer	CCLE	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0833
p.M618K	NCI-H1573	lung	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0833
p.E398K	TCGA-TQ-A7RW	LGG	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1389
p.P623A	TCGA-VQ-AA6B	STAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2222
p.M617I	TCGA-ZG-A9N3	PRAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0556
p.S386C	DO219008	BLCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.7541
p.G639R	DO218684	BRCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7568
p.R625Q	DO225209	BRCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2778
p.D563N	DO5200	BRCA	ICGC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.1389
p.E561K	DO49976	CESC	ICGC	PPFY	ITCH	570:573	Mutation blocking phosphorylation signal	0.5278
p.R375P	DO44299	CESC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1111
p.S642F	DO50090	COAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2778
p.S634L	DO7801	COAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO36881	READ	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO37429	SKCM	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO51766	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO51751	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO43041	UCEC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO42713	UCEC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.R393C	DO228927	COCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.2778
p.R393C	DO50076	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.2778
p.R393C	DO41903	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.2778
p.R393C	DO41331	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.2778
p.R391H	DO222762	COCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8244
p.R391H	DO233748	GACA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8244
p.R391H	DO11842	GBM	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8244
p.C581Y	DO233930	GACA	ICGC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.1111
p.E632Q	DO15791	HNSC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.6744
p.S642C	DO52106	HNSC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2778
p.S395I	DO218923	LUAD	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.2222
p.P565T	DO23891	LUAD	ICGC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.1944
p.A396G	DO26015	LUAD	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation substituting flanking lysine	0.3056
p.N397H	DO231043	LUSC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.1667
p.P400S	DO220902	MELA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.P400S	DO218912	SKCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0833
p.S631F	DO222662	MELA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7982
p.S387Y	DO222875	MELA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.712
p.E632V	DO50085	OV	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7693
p.E640K	DO51720	PAAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7022
p.A570T	DO232224	PBCA	ICGC	PPFY	ITCH	570:573	Mutation altering degron motif	0.7139
p.R389Q	DO49828	PRAD	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.7329
p.R389Q	DO50076	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.7329
p.P636T	DO220011	SARC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7031
p.E632G	DO38400	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7199
p.E622K	DO48009	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.1944
p.R625W	DO47867	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2778
p.G639C	DO39088	THCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.76
p.D562Y	DO41758	UCEC	ICGC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.1111
p.I646F	SIDM00683	Prostate Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.1667
p.A628E	SIDM01151	Hepatocellular Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7701
p.A628E	ACH-000483	Liver Cancer	CCLE	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7701
p.A628E	SNU-182	liver	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7701
p.P623H	SIDM01117	Small Cell Lung Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2222
p.P623H	SIDM01409	Bladder Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2222
p.P373L	SIDM01175	Other Sarcomas	GDSC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0556
p.P373L	ACH-002309	Sarcoma	CCLE	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0556
p.P373L	SW684	soft tissue	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.0556
p.V640L	SIDM00633	Breast Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.5654
p.V640L	ACH-000759	Breast Cancer	CCLE	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.5654
p.V640L	MDA-MB-175-VII	breast	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.5654
p.S561C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	PPFY	ITCH	570:573	Mutation blocking phosphorylation signal	0.5278
p.S561C	ACH-000309	Lung Cancer	CCLE	PPFY	ITCH	570:573	Mutation blocking phosphorylation signal	0.5278
p.S561C	SK-LU-1	lung	COSMIC	PPFY	ITCH	570:573	Mutation blocking phosphorylation signal	0.5278
p.R631W	SNU-1040	large intestine	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.8634
p.D642E	KP-2	pancreas	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.2778
p.V385L	AU565	breast	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.6765
p.A561E	SNU-182	liver	COSMIC	PPFY	ITCH	570:573	Mutation blocking phosphorylation signal	0.5278
p.T388A	HCC2998	large intestine	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.6028
p.D567G	EN	endometrium	COSMIC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.25
p.G566E	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.2222
p.S387C	SK-LU-1	lung	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.7541
p.Y617H	SNU-283	large intestine	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation rewiring degron network	0.0556
p.T382A	NCI-H2110	lung	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.3056
p.H569Q	TT2609-C02	thyroid	COSMIC	PPFY	ITCH	570:573	Mutation rewiring degron network	0.3056
p.A395V	NCI-H630	large intestine	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation rewiring degron network	0.2222
p.R640G	TGBC11TKB	stomach	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7568
p.S634P	639-V	urinary tract	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.6752
p.V573L	MDA-MB-175-VII	breast	COSMIC	PPFY	ITCH	570:573	Mutation altering degron motif	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BNC2

UniProt ID: Q6ZN30

Entrez ID: 54796

Protein name: Zinc finger protein basonuclin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BNC2 in