DegronMD - Q6ZN30(BNC2)

FUNCTION: Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). {ECO:0000269|PubMed:14988505, ECO:0000269|PubMed:31051115}.

GO - Biological processes (BP): endochondral bone growth [GO:0003416]; mesenchyme development [GO:0060485]; regulation of transcription, DNA-templated [GO:0006355]; roof of mouth development [GO:0060021]; tongue development [GO:0043586]

GO - Molecular function (MF): metal ion binding [GO:0046872]; rDNA binding [GO:0000182]

GO - Cellular component (CC): chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
NRNALTSIT	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Zinc finger protein basonuclin-2	383:391	More..
LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	VHL	Zinc finger protein basonuclin-2	627:640	More..
PPFY	ITCH	ITCH,NEDD4	Zinc finger protein basonuclin-2	570:573	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R631W	SNU-1040	large intestine	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.8634
p.R391H	DO222762	COCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8244
p.R391H	DO233748	GACA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8244
p.R391H	DO11842	GBM	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.8244
p.S631F	DO222662	MELA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7982
p.A628E	SIDM01151	Hepatocellular Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7701
p.A628E	ACH-000483	Liver Cancer	CCLE	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7701
p.A628E	SNU-182	liver	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7701
p.E632V	DO50085	OV	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7693
p.S634L	DO7801	COAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO36881	READ	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO37429	SKCM	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO51766	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO51751	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO43041	UCEC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.S634L	DO42713	UCEC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7667
p.G639C	DO39088	THCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.76
p.G639R	DO218684	BRCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7568
p.R640G	TGBC11TKB	stomach	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	627:640	Mutation altering degron motif	0.7568
p.S386C	DO219008	BLCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	383:391	Mutation altering degron motif	0.7541

Showing 1 to 20 of 103 entries

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No resistance data available for this Degron.

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

BNC2

UniProt ID: Q6ZN30

Entrez ID: 54796

Protein name: Zinc finger protein basonuclin-2

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for BNC2 in