DegronMD

Uniprot ID: Q6ZN30

Source protein: Zinc finger protein basonuclin-2

Source gene: BNC2

Class: DEG_APCC_DBOX_1

Location: 383:391

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7927

ASA_SCORE: 95.6556

COIL: 0.8524

CONS_SCORE: 0.314

DSS_SCORE: 0.6515

HELIX: 0.1236

FCONS_SCORE: 0.7416

RIG_SCORE: 0.7013

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P382R	TCGA-13-0920	OV	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	0.3056
p.T391N	TCGA-60-2714	LUSC	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	0.5944
p.N392K	TCGA-AJ-A3EK	UCEC	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	0.3056
p.T391A	TCGA-AX-A0J1	UCEC	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	0.6028
p.T374A	TCGA-IB-7651	PAAD	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	0.0833
p.E398K	TCGA-TQ-A7RW	LGG	TCGA	NRNALTSIT	DEG_APCC_DBOX_1	0.1389
p.S386C	DO219008	BLCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.7541
p.R375P	DO44299	CESC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.1111
p.R393C	DO228927	COCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.2778
p.R393C	DO50076	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.2778
p.R393C	DO41903	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.2778
p.R393C	DO41331	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.2778
p.R391H	DO222762	COCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.8244
p.R391H	DO233748	GACA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.8244
p.R391H	DO11842	GBM	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.8244
p.S395I	DO218923	LUAD	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.2222
p.A396G	DO26015	LUAD	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.3056
p.N397H	DO231043	LUSC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.1667
p.P400S	DO220902	MELA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.0833
p.P400S	DO218912	SKCA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.0833
p.S387Y	DO222875	MELA	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.712
p.R389Q	DO49828	PRAD	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.7329
p.R389Q	DO50076	UCEC	ICGC	NRNALTSIT	DEG_APCC_DBOX_1	0.7329
p.P373L	SIDM01175	Other Sarcomas	GDSC	NRNALTSIT	DEG_APCC_DBOX_1	0.0556
p.P373L	ACH-002309	Sarcoma	CCLE	NRNALTSIT	DEG_APCC_DBOX_1	0.0556
p.P373L	SW684	soft_tissue	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	0.0556
p.V385L	AU565	breast	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	0.6765
p.T388A	HCC2998	large_intestine	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	0.6028
p.S387C	SK-LU-1	lung	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	0.7541
p.T382A	NCI-H2110	lung	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	0.3056
p.A395V	NCI-H630	large_intestine	COSMIC	NRNALTSIT	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRNALTSIT

Degron related mutations and impact score

Drug responses associated with BNC2 mutations

All proteins holding degron of NRNALTSIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN30	Zinc finger protein basonuclin-2	DEG_APCC_DBOX_1	383:391	NRNALTSIT	APC,CDC20,FZR1	0.7927	More...