DegronMD

Uniprot ID: Q6ZN30

Source protein: Zinc finger protein basonuclin-2

Source gene: BNC2

Class: DEG_ODPH_VHL_1

Location: 627:640

E3 ligase: VHL

DEGRON score: 0.9605

ASA_SCORE: 110.6429

COIL: 0.8906

CONS_SCORE: 0.6395

DSS_SCORE: 0.6254

HELIX: 0.0755

FCONS_SCORE: 1.7046

RIG_SCORE: 0.6452

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H621L	TCGA-86-8073	LUAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.1667
p.P623S	TCGA-AP-A059	UCEC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2222
p.P623S	DO229039	LICA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2222
p.K630N	TCGA-CA-6718	COAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.5806
p.K630M	TCGA-CV-5442	HNSC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.6951
p.A650V	TCGA-D1-A17Q	UCEC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0556
p.P639S	TCGA-EE-A3AF	SKCM	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.5641
p.A650T	TCGA-EO-A22U	UCEC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0556
p.H621Y	TCGA-G3-A25T	LIHC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.1667
p.M618K	TCGA-PK-A5HB	ACC	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0833
p.M618K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0833
p.M618K	ACH-000916	Lung Cancer	CCLE	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0833
p.M618K	NCI-H1573	lung	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0833
p.P623A	TCGA-VQ-AA6B	STAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2222
p.M617I	TCGA-ZG-A9N3	PRAD	TCGA	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0556
p.G639R	DO218684	BRCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7568
p.R625Q	DO225209	BRCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2778
p.S642F	DO50090	COAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2778
p.S634L	DO7801	COAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7667
p.S634L	DO36881	READ	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7667
p.S634L	DO37429	SKCM	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7667
p.S634L	DO51766	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7667
p.S634L	DO51751	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7667
p.S634L	DO43041	UCEC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7667
p.S634L	DO42713	UCEC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7667
p.E632Q	DO15791	HNSC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.6744
p.S642C	DO52106	HNSC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2778
p.S631F	DO222662	MELA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7982
p.E632V	DO50085	OV	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7693
p.E640K	DO51720	PAAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7022
p.P636T	DO220011	SARC	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7031
p.E632G	DO38400	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7199
p.E622K	DO48009	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.1944
p.R625W	DO47867	STAD	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2778
p.G639C	DO39088	THCA	ICGC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.76
p.I646F	SIDM00683	Prostate Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.1667
p.A628E	SIDM01151	Hepatocellular Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7701
p.A628E	ACH-000483	Liver Cancer	CCLE	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7701
p.A628E	SNU-182	liver	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7701
p.P623H	SIDM01117	Small Cell Lung Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2222
p.P623H	SIDM01409	Bladder Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2222
p.V640L	SIDM00633	Breast Carcinoma	GDSC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.5654
p.V640L	ACH-000759	Breast Cancer	CCLE	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.5654
p.V640L	MDA-MB-175-VII	breast	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.5654
p.R631W	SNU-1040	large_intestine	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.8634
p.D642E	KP-2	pancreas	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.2778
p.Y617H	SNU-283	large_intestine	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.0556
p.R640G	TGBC11TKB	stomach	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.7568
p.S634P	639-V	urinary_tract	COSMIC	LAPKKKPRKSSMPV	DEG_ODPH_VHL_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPKKKPRKSSMPV

Degron related mutations and impact score

Drug responses associated with BNC2 mutations

All proteins holding degron of LAPKKKPRKSSMPV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN30	Zinc finger protein basonuclin-2	DEG_ODPH_VHL_1	627:640	LAPKKKPRKSSMPV	VHL	0.9605	More...