DegronMD

Uniprot ID: Q6ZN30

Source protein: Zinc finger protein basonuclin-2

Source gene: BNC2

Class: ITCH

Location: 570:573

E3 ligase: ITCH,NEDD4

DEGRON score: 0.7924

ASA_SCORE: 90.05

COIL: 0.835

CONS_SCORE: 0.374

DSS_SCORE: 0.3601

HELIX: 0.1348

FCONS_SCORE: 0.8102

RIG_SCORE: 0.7875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S575R	TCGA-17-Z028	LUAD	TCGA	PPFY	ITCH	0.2778
p.S575R	TCGA-AA-3975	COAD	TCGA	PPFY	ITCH	0.2778
p.S575R	TCGA-CD-8524	STAD	TCGA	PPFY	ITCH	0.2778
p.S575R	TCGA-CD-A48C	STAD	TCGA	PPFY	ITCH	0.2778
p.S575R	TCGA-D7-6525	STAD	TCGA	PPFY	ITCH	0.2778
p.S575R	SIDM01296	Esophageal Carcinoma	GDSC	PPFY	ITCH	0.2778
p.S575I	TCGA-BR-8370	STAD	TCGA	PPFY	ITCH	0.2778
p.E581K	TCGA-D3-A2JF	SKCM	TCGA	PPFY	ITCH	0.1111
p.R574G	TCGA-EL-A3ZR	THCA	TCGA	PPFY	ITCH	0.3056
p.D563N	DO5200	BRCA	ICGC	PPFY	ITCH	0.1389
p.E561K	DO49976	CESC	ICGC	PPFY	ITCH	0.5278
p.C581Y	DO233930	GACA	ICGC	PPFY	ITCH	0.1111
p.P565T	DO23891	LUAD	ICGC	PPFY	ITCH	0.1944
p.A570T	DO232224	PBCA	ICGC	PPFY	ITCH	0.7139
p.D562Y	DO41758	UCEC	ICGC	PPFY	ITCH	0.1111
p.S561C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	PPFY	ITCH	0.5278
p.S561C	ACH-000309	Lung Cancer	CCLE	PPFY	ITCH	0.5278
p.S561C	SK-LU-1	lung	COSMIC	PPFY	ITCH	0.5278
p.A561E	SNU-182	liver	COSMIC	PPFY	ITCH	0.5278
p.D567G	EN	endometrium	COSMIC	PPFY	ITCH	0.25
p.G566E	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.2222
p.H569Q	TT2609-C02	thyroid	COSMIC	PPFY	ITCH	0.3056
p.V573L	MDA-MB-175-VII	breast	COSMIC	PPFY	ITCH	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17643	5,6-dihydroxyindole-2-carboxylic acid oxidase	ITCH	345:348	PPFY	ITCH,NEDD4	0.695	More...
P18583	Protein SON	ITCH	2136:2139	PPFY	ITCH,NEDD4	0.9982	More...
P78563	Double-stranded RNA-specific editase 1	ITCH	188:191	PPFY	ITCH,NEDD4	0.9978	More...
Q16644	MAP kinase-activated protein kinase 3	ITCH	240:243	PPFY	ITCH,NEDD4	0.6619	More...
Q5TBA9	Protein furry homolog	ITCH	1514:1517	PPFY	ITCH,NEDD4	0.7858	More...
Q5VTD9	Zinc finger protein Gfi-1b	ITCH	99:102	PPFY	ITCH,NEDD4	0.9889	More...
Q5VYJ5	MAM and LDL-receptor class A domain-containing protein 1	ITCH	103:106	PPFY	ITCH,NEDD4	0.6037	More...
Q6ZN30	Zinc finger protein basonuclin-2	ITCH	570:573	PPFY	ITCH,NEDD4	0.7924	More...
Q8IW41	MAP kinase-activated protein kinase 5	ITCH	239:242	PPFY	ITCH,NEDD4	0.887	More...
Q9UPX0	Protein turtle homolog B	ITCH	981:984	PPFY	ITCH,NEDD4	0.9332	More...
Q6ZTI6	Refilin-A	ITCH	38:41	PPFY	ITCH,NEDD4	0.9921	More...
Q7Z2T5	TRMT1-like protein	ITCH	632:635	PPFY	ITCH,NEDD4	0.8239	More...
A4D0V7	Cadherin-like and PC-esterase domain-containing protein 1	ITCH	104:107	PPFY	ITCH,NEDD4	0.9116	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	4949:4952	PPFY	ITCH,NEDD4	0.8101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons