DegronMD

Uniprot ID: P78563

Source protein: Double-stranded RNA-specific editase 1

Source gene: ADARB1

Class: ITCH

Location: 188:191

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9978

ASA_SCORE: 62.625

COIL: 0.7988

CONS_SCORE: 0.443

DSS_SCORE: 0.6259

HELIX: 0.0545

FCONS_SCORE: 1.0476

RIG_SCORE: 0.7425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P183S	TCGA-A5-A0G2	UCEC	TCGA	PPFY	ITCH	0.1944
p.P183S	DO41235	UCEC	ICGC	PPFY	ITCH	0.1944
p.A186V	TCGA-AA-3947	COAD	TCGA	PPFY	ITCH	0.2778
p.A186V	DO8192	COAD	ICGC	PPFY	ITCH	0.2778
p.A186V	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PPFY	ITCH	0.2778
p.A186V	SIDM00316	Glioblastoma	GDSC	PPFY	ITCH	0.2778
p.A186V	SIDM01622	Breast Carcinoma	GDSC	PPFY	ITCH	0.2778
p.A186V	SIDM00171	Colorectal Carcinoma	GDSC	PPFY	ITCH	0.2778
p.A186V	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.2778
p.A186V	YH-13	central_nervous_system	COSMIC	PPFY	ITCH	0.2778
p.P183L	TCGA-AP-A1DK	UCEC	TCGA	PPFY	ITCH	0.1944
p.P183L	DO42033	UCEC	ICGC	PPFY	ITCH	0.1944
p.G196V	TCGA-DU-7298	LGG	TCGA	PPFY	ITCH	0.1944
p.G196V	DO22679	LGG	ICGC	PPFY	ITCH	0.1944
p.P189S	TCGA-FS-A1ZK	SKCM	TCGA	PPFY	ITCH	0.6752
p.P189S	DO222837	MELA	ICGC	PPFY	ITCH	0.6752
p.P189S	DO37474	SKCM	ICGC	PPFY	ITCH	0.6752
p.P188S	DO227709	COCA	ICGC	PPFY	ITCH	0.6752
p.G179C	DO229006	LICA	ICGC	PPFY	ITCH	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17643	5,6-dihydroxyindole-2-carboxylic acid oxidase	ITCH	345:348	PPFY	ITCH,NEDD4	0.695	More...
P18583	Protein SON	ITCH	2136:2139	PPFY	ITCH,NEDD4	0.9982	More...
P78563	Double-stranded RNA-specific editase 1	ITCH	188:191	PPFY	ITCH,NEDD4	0.9978	More...
Q16644	MAP kinase-activated protein kinase 3	ITCH	240:243	PPFY	ITCH,NEDD4	0.6619	More...
Q5TBA9	Protein furry homolog	ITCH	1514:1517	PPFY	ITCH,NEDD4	0.7858	More...
Q5VTD9	Zinc finger protein Gfi-1b	ITCH	99:102	PPFY	ITCH,NEDD4	0.9889	More...
Q5VYJ5	MAM and LDL-receptor class A domain-containing protein 1	ITCH	103:106	PPFY	ITCH,NEDD4	0.6037	More...
Q6ZN30	Zinc finger protein basonuclin-2	ITCH	570:573	PPFY	ITCH,NEDD4	0.7924	More...
Q8IW41	MAP kinase-activated protein kinase 5	ITCH	239:242	PPFY	ITCH,NEDD4	0.887	More...
Q9UPX0	Protein turtle homolog B	ITCH	981:984	PPFY	ITCH,NEDD4	0.9332	More...
Q6ZTI6	Refilin-A	ITCH	38:41	PPFY	ITCH,NEDD4	0.9921	More...
Q7Z2T5	TRMT1-like protein	ITCH	632:635	PPFY	ITCH,NEDD4	0.8239	More...
A4D0V7	Cadherin-like and PC-esterase domain-containing protein 1	ITCH	104:107	PPFY	ITCH,NEDD4	0.9116	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	4949:4952	PPFY	ITCH,NEDD4	0.8101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons