DegronMD - Q5TBA9(FRY)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1975L	TCGA-09-2044	OV	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1111
p.R1975L	DO28923	OV	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1111
p.D2489Y	TCGA-13-0916	OV	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.6214
p.D2489Y	DO32566	OV	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.6214
p.N1969Y	TCGA-17-Z031	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.2778
p.V952L	TCGA-2H-A9GL	ESCA	TCGA	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation rewiring degron network	0.3056
p.C2494S	TCGA-33-4586	LUSC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2778
p.C2494S	DO27318	LUSC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2778
p.E1974V	TCGA-44-2656	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1389
p.E1974V	DO26052	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1389
p.N2480I	TCGA-56-A62T	LUSC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.N2480I	DO219144	LUSC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.G960D	TCGA-58-A46L	LUSC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation rewiring degron network	0.0833
p.G960D	DO45434	LUSC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation rewiring degron network	0.0833
p.S1764G	TCGA-85-A5B5	LUSC	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1389
p.S1764G	DO50102	LUSC	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1389
p.A945V	TCGA-A5-A1OF	UCEC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.5825
p.A945V	TCGA-AJ-A3OJ	UCEC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.5825
p.A945V	DO42568	UCEC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.5825
p.A945V	DO42753	UCEC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.5825
p.P1514L	TCGA-AA-3561	COAD	TCGA	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7582
p.P1514L	DO10790	COAD	ICGC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7582
p.E1974K	TCGA-AG-A002	READ	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1389
p.E1974K	TCGA-D1-A15X	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1389
p.E1974K	DO43274	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1389
p.R1518H	TCGA-AP-A051	UCEC	TCGA	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.3056
p.R1518H	DO42673	UCEC	ICGC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.3056
p.R1518H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.3056
p.R1518H	ACH-002059	Leukemia	CCLE	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.3056
p.R1518H	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.3056
p.R2484C	TCGA-AP-A051	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.719
p.R2484C	TCGA-FI-A2D0	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.719
p.R2484C	TCGA-FI-A2D5	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.719
p.R2484C	DO43891	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.719
p.R2484C	DO42673	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.719
p.R2484C	DO41331	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.719
p.R2484H	TCGA-AX-A0J1	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.7133
p.R2484H	DO41199	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.7133
p.A1973D	TCGA-AY-6197	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1667
p.A1973D	DO9956	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1667
p.E2500Q	TCGA-C8-A8HQ	BRCA	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.1111
p.E2500Q	TCGA-S5-A6DX	BLCA	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.1111
p.E2500Q	DO51903	BLCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.1111
p.E2500Q	DO219623	BRCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.1111
p.S1764I	TCGA-CA-6717	COAD	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1389
p.S1764I	DO8264	COAD	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1389
p.P1963Q	TCGA-D3-A2JO	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation altering degron motif	0.7035
p.P1963Q	DO47619	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation altering degron motif	0.7035
p.K957N	TCGA-D3-A3CE	SKCM	TCGA	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation substituting flanking lysine	0.2778
p.K957N	DO37405	SKCM	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation substituting flanking lysine	0.2778
p.P1515S	TCGA-D5-6530	COAD	TCGA	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.6752
p.P1515S	TCGA-VQ-A8E0	STAD	TCGA	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.6752
p.P1515S	DO8312	COAD	ICGC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.6752
p.P1515S	DO51757	STAD	ICGC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.6752
p.C2494Y	TCGA-EM-A2OV	THCA	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2778
p.C2494Y	DO39684	THCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2778
p.R1975W	TCGA-EO-A3AV	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1111
p.R1975W	DO222817	BTCA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1111
p.R1975W	DO52412	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1111
p.D1744G	TCGA-FI-A2D5	UCEC	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1389
p.D1744G	DO41331	UCEC	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1389
p.K957E	TCGA-FI-A2F4	UCEC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation substituting flanking lysine	0.2778
p.K957E	DO43434	UCEC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation substituting flanking lysine	0.2778
p.P1963L	TCGA-FP-A4BE	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation altering degron motif	0.7582
p.P1963L	DO233253	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation altering degron motif	0.7582
p.P1963L	DO233903	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation altering degron motif	0.7582
p.P1963L	DO48016	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation altering degron motif	0.7582
p.S2490I	TCGA-X6-A7WB	SARC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.7341
p.S2490I	DO220314	SARC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.7341
p.G1968S	DO49292	ALL	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.3056
p.R2502H	DO50466	BOCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.0556
p.V1508I	DO225207	BRCA	ICGC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.1667
p.V1508I	SIDM00683	Prostate Carcinoma	GDSC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.1667
p.R1742K	DO228722	EOPC	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.0833
p.R1518C	DO228544	GACA	ICGC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.3056
p.R1977Q	DO233254	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.0556
p.R1977Q	SIDM00151	Ovarian Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.0556
p.R1977Q	ACH-000966	Ovarian Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.0556
p.R1977Q	IGROV-1	ovary	COSMIC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.0556
p.G950C	DO228976	LICA	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.6489
p.A938S	DO229029	LICA	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation rewiring degron network	0.1667
p.G1968V	DO229028	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.3056
p.G1957R	DO229058	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1667
p.A1971P	DO220891	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.2222
p.S1760F	DO222843	MELA	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.25
p.R2486G	DO31150	OV	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.6457
p.S1747F	DO34736	PACA	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.2222
p.D949N	DO35242	PACA	ICGC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.5821
p.R1977W	DO232224	PBCA	ICGC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.0556
p.V1504M	SIDM00281	Other Solid Cancers	GDSC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0556
p.V1504M	ACH-002100	Skin Cancer	CCLE	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0556
p.V1504M	DJM-1	skin	COSMIC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0556
p.Y1517H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7229
p.Y1517H	ACH-000860	Lung Cancer	CCLE	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7229
p.Y1517H	NCI-H358	lung	COSMIC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7229
p.M2496T	SIDM00795	Melanoma	GDSC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.M2496T	ACH-000219	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.M2496T	ACH-002001	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.M2496T	ACH-002002	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.M2496T	ACH-002003	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.M2496T	A375	skin	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.A1527V	SIDM00660	Colorectal Carcinoma	GDSC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0556
p.A1527V	ACH-000985	Colon/Colorectal Cancer	CCLE	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0556
p.A1527V	LS-411N	large intestine	COSMIC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0556
p.G1957E	SIDM00272	Breast Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1667
p.G1957E	ACH-000910	Breast Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1667
p.G1957E	MDA-MB-453	breast	COSMIC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1667
p.D2489N	SIDM00527	Colorectal Carcinoma	GDSC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.5821
p.D2489N	ACH-000935	Colon/Colorectal Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.5821
p.D2489N	MDST8	large intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.5821
p.K2493M	SIDM00316	Glioblastoma	GDSC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.3056
p.K2493M	ACH-000469	Brain Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.3056
p.K2493M	YH-13	central nervous system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.3056
p.V1508A	ACH-001130	Lymphoma	CCLE	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.1667
p.D1512G	ACH-001533	Lymphoma	CCLE	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.2778
p.M2495T	A375	skin	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.25
p.L1967M	CAKI-1	kidney	COSMIC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation altering degron motif	0.711
p.L1517R	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.8428
p.D2488N	MDST8	large intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.6932
p.S1743P	CW-2	large intestine	COSMIC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1111
p.D2492N	MDST8	large intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.5821
p.N1747I	HOP-92	lung	COSMIC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.2222
p.Y1517C	NCI-H630	large intestine	COSMIC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7087
p.R1517H	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.8244
p.S2477R	PL18	pancreas	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.1389
p.Y1516C	NCI-H630	large intestine	COSMIC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7087
p.G1956E	MDA-MB-453	breast	COSMIC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation blocking phosphorylation signal	0.5833
p.S2487P	ONS-76	central nervous system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.6752
p.R1521H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.2222
p.Y1516H	NCI-H358	lung	COSMIC	PPFY	ITCH	1514:1517	Mutation altering degron motif	0.7229
p.G1762V	TGBC11TKB	stomach	COSMIC	DSGLSSS	DEG_SCF_TRCP1_1	1751:1757	Mutation rewiring degron network	0.1944
p.R1976Q	IGROV-1	ovary	COSMIC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.0833
p.M2499T	A375	skin	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.1389
p.V947F	LB996-RCC	kidney	COSMIC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.7068
p.K2496M	YH-13	central nervous system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2222
p.K2492M	YH-13	central nervous system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.8062
p.A1526V	LS-411N	large intestine	COSMIC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0833
p.R1955I	COLO-800	skin	COSMIC	PGTTS	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1111
p.T947A	HCC2998	large intestine	COSMIC	MATTPDGT	DEG_SCF_FBW7_1	944:951	Mutation altering degron motif	0.7139
p.S2494P	KYSE-150	oesophagus	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation rewiring degron network	0.2778
p.I1504M	OVK-18	ovary	COSMIC	PPFY	ITCH	1514:1517	Mutation rewiring degron network	0.0556
p.N2490S	SNU-1040	large intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	2484:2492	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRY

UniProt ID: Q5TBA9

Entrez ID: 10129

Protein name: Protein furry homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRY in