DegronMD

Uniprot ID: Q5TBA9

Source protein: Protein furry homolog

Source gene: FRY

Class: DEG_SCF_TRCP1_1

Location: 1751:1757

E3 ligase: BTRC

DEGRON score: 0.946

ASA_SCORE: 69.7286

COIL: 0.874

CONS_SCORE: 0.2873

DSS_SCORE: 0.6387

HELIX: 0.0943

FCONS_SCORE: 1.019

RIG_SCORE: 0.5703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1764G	TCGA-85-A5B5	LUSC	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.S1764G	DO50102	LUSC	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.S1764I	TCGA-CA-6717	COAD	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.S1764I	DO8264	COAD	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.D1744G	TCGA-FI-A2D5	UCEC	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.D1744G	DO41331	UCEC	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.R1742K	DO228722	EOPC	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.0833
p.S1760F	DO222843	MELA	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.25
p.S1747F	DO34736	PACA	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.2222
p.S1743P	CW-2	large_intestine	COSMIC	DSGLSSS	DEG_SCF_TRCP1_1	0.1111
p.N1747I	HOP-92	lung	COSMIC	DSGLSSS	DEG_SCF_TRCP1_1	0.2222
p.G1762V	TGBC11TKB	stomach	COSMIC	DSGLSSS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TBA9	Protein furry homolog	DEG_SCF_TRCP1_1	1751:1757	DSGLSSS	BTRC	0.946	More...
Q8NA03	Fibrous sheath-interacting protein 1	DEG_SCF_TRCP1_1	290:296	DSGLSSS	BTRC	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons