DegronMD

Uniprot ID: Q8NA03

Source protein: Fibrous sheath-interacting protein 1

Source gene: FSIP1

Class: DEG_SCF_TRCP1_1

Location: 290:296

E3 ligase: BTRC

DEGRON score: 0.9957

ASA_SCORE: 77.1429

COIL: 0.8707

CONS_SCORE: 0.8745

DSS_SCORE: 0.5043

HELIX: 0.1037

FCONS_SCORE: 1.2912

RIG_SCORE: 0.6356

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L283S	TCGA-BF-AAOX	SKCM	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.L283S	DO223907	SKCM	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.1389
p.P306L	TCGA-KQ-A41Q	BLCA	TCGA	DSGLSSS	DEG_SCF_TRCP1_1	0.0556
p.P306L	DO223591	BLCA	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.0556
p.G292R	DO233272	GACA	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.7568
p.V280A	DO50937	LICA	ICGC	DSGLSSS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TBA9	Protein furry homolog	DEG_SCF_TRCP1_1	1751:1757	DSGLSSS	BTRC	0.946	More...
Q8NA03	Fibrous sheath-interacting protein 1	DEG_SCF_TRCP1_1	290:296	DSGLSSS	BTRC	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons