DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
FSIP1
UniProt ID:
Q8NA03
Entrez ID:
161835
Protein name:
Fibrous sheath-interacting protein 1
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
FSIP1
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.L283S
TCGA-BF-AAOX
SKCM
TCGA
DSGLSSS
DEG_SCF_TRCP1_1
290:296
Mutation rewiring degron network
0.1389
p.L283S
DO223907
SKCM
ICGC
DSGLSSS
DEG_SCF_TRCP1_1
290:296
Mutation rewiring degron network
0.1389
p.P306L
TCGA-KQ-A41Q
BLCA
TCGA
DSGLSSS
DEG_SCF_TRCP1_1
290:296
Mutation rewiring degron network
0.0556
p.P306L
DO223591
BLCA
ICGC
DSGLSSS
DEG_SCF_TRCP1_1
290:296
Mutation rewiring degron network
0.0556
p.G292R
DO233272
GACA
ICGC
DSGLSSS
DEG_SCF_TRCP1_1
290:296
Mutation altering degron motif
0.7568
p.V280A
DO50937
LICA
ICGC
DSGLSSS
DEG_SCF_TRCP1_1
290:296
Mutation rewiring degron network
0.0556
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for FSIP1 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc