DegronMD

Uniprot ID: Q5TBA9

Source protein: Protein furry homolog

Source gene: FRY

Class: DEG_SCF_FBW7_1

Location: 944:951

E3 ligase: FBXW7

DEGRON score: 0.9384

ASA_SCORE: 81.3375

COIL: 0.8755

CONS_SCORE: 0.3029

DSS_SCORE: 0.4002

HELIX: 0.0716

FCONS_SCORE: 1.0306

RIG_SCORE: 0.7132

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T947A	HCC2998	large_intestine	COSMIC	MATTPDGT	DEG_SCF_FBW7_1	0.7139
p.V947F	LB996-RCC	kidney	COSMIC	MATTPDGT	DEG_SCF_FBW7_1	0.7068
p.G950C	DO228976	LICA	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.6489
p.A945V	TCGA-A5-A1OF	UCEC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	0.5825
p.A945V	TCGA-AJ-A3OJ	UCEC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	0.5825
p.A945V	DO42568	UCEC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.5825
p.A945V	DO42753	UCEC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.5825
p.D949N	DO35242	PACA	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.5821
p.V952L	TCGA-2H-A9GL	ESCA	TCGA	MATTPDGT	DEG_SCF_FBW7_1	0.3056
p.K957N	TCGA-D3-A3CE	SKCM	TCGA	MATTPDGT	DEG_SCF_FBW7_1	0.2778
p.K957N	DO37405	SKCM	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.2778
p.K957E	TCGA-FI-A2F4	UCEC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	0.2778
p.K957E	DO43434	UCEC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.2778
p.A938S	DO229029	LICA	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.1667
p.G960D	TCGA-58-A46L	LUSC	TCGA	MATTPDGT	DEG_SCF_FBW7_1	0.0833
p.G960D	DO45434	LUSC	ICGC	MATTPDGT	DEG_SCF_FBW7_1	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TBA9	Protein furry homolog	DEG_SCF_FBW7_1	944:951	MATTPDGT	FBXW7	0.9384	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons