DegronMD

Uniprot ID: Q5TBA9

Source protein: Protein furry homolog

Source gene: FRY

Class: DEG_APCC_DBOX_1

Location: 2484:2492

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9708

ASA_SCORE: 72.6778

COIL: 0.6308

CONS_SCORE: 0.3326

DSS_SCORE: 0.2663

HELIX: 0.2524

FCONS_SCORE: 1.0887

RIG_SCORE: 0.7906

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2489Y	TCGA-13-0916	OV	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.6214
p.D2489Y	DO32566	OV	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.6214
p.C2494S	TCGA-33-4586	LUSC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.2778
p.C2494S	DO27318	LUSC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.2778
p.N2480I	TCGA-56-A62T	LUSC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.N2480I	DO219144	LUSC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.R2484C	TCGA-AP-A051	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.719
p.R2484C	TCGA-FI-A2D0	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.719
p.R2484C	TCGA-FI-A2D5	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.719
p.R2484C	DO43891	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.719
p.R2484C	DO42673	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.719
p.R2484C	DO41331	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.719
p.R2484H	TCGA-AX-A0J1	UCEC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.7133
p.R2484H	DO41199	UCEC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.7133
p.E2500Q	TCGA-C8-A8HQ	BRCA	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.1111
p.E2500Q	TCGA-S5-A6DX	BLCA	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.1111
p.E2500Q	DO51903	BLCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.1111
p.E2500Q	DO219623	BRCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.1111
p.C2494Y	TCGA-EM-A2OV	THCA	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.2778
p.C2494Y	DO39684	THCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.2778
p.S2490I	TCGA-X6-A7WB	SARC	TCGA	RRRSLDSLD	DEG_APCC_DBOX_1	0.7341
p.S2490I	DO220314	SARC	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.7341
p.R2502H	DO50466	BOCA	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.0556
p.R2486G	DO31150	OV	ICGC	RRRSLDSLD	DEG_APCC_DBOX_1	0.6457
p.M2496T	SIDM00795	Melanoma	GDSC	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.M2496T	ACH-000219	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.M2496T	ACH-002001	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.M2496T	ACH-002002	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.M2496T	ACH-002003	Skin Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.M2496T	A375	skin	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.D2489N	SIDM00527	Colorectal Carcinoma	GDSC	RRRSLDSLD	DEG_APCC_DBOX_1	0.5821
p.D2489N	ACH-000935	Colon/Colorectal Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	0.5821
p.D2489N	MDST8	large_intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.5821
p.K2493M	SIDM00316	Glioblastoma	GDSC	RRRSLDSLD	DEG_APCC_DBOX_1	0.3056
p.K2493M	ACH-000469	Brain Cancer	CCLE	RRRSLDSLD	DEG_APCC_DBOX_1	0.3056
p.K2493M	YH-13	central_nervous_system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.3056
p.M2495T	A375	skin	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.25
p.D2488N	MDST8	large_intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.6932
p.D2492N	MDST8	large_intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.5821
p.S2477R	PL18	pancreas	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.1389
p.S2487P	ONS-76	central_nervous_system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.6752
p.M2499T	A375	skin	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.1389
p.K2496M	YH-13	central_nervous_system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.2222
p.K2492M	YH-13	central_nervous_system	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.8062
p.S2494P	KYSE-150	oesophagus	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.2778
p.N2490S	SNU-1040	large_intestine	COSMIC	RRRSLDSLD	DEG_APCC_DBOX_1	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRSLDSLD

Degron related mutations and impact score

Drug responses associated with FRY mutations

All proteins holding degron of RRRSLDSLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TBA9	Protein furry homolog	DEG_APCC_DBOX_1	2484:2492	RRRSLDSLD	APC,CDC20,FZR1	0.9708	More...