DegronMD

Uniprot ID: Q5TBA9

Source protein: Protein furry homolog

Source gene: FRY

Class: ITCH

Location: 1514:1517

E3 ligase: ITCH,NEDD4

DEGRON score: 0.7858

ASA_SCORE: 47.4

COIL: 0.694

CONS_SCORE: 0.3706

DSS_SCORE: 0.3449

HELIX: 0.0488

FCONS_SCORE: 1.1369

RIG_SCORE: 0.7927

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1514L	TCGA-AA-3561	COAD	TCGA	PPFY	ITCH	0.7582
p.P1514L	DO10790	COAD	ICGC	PPFY	ITCH	0.7582
p.R1518H	TCGA-AP-A051	UCEC	TCGA	PPFY	ITCH	0.3056
p.R1518H	DO42673	UCEC	ICGC	PPFY	ITCH	0.3056
p.R1518H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPFY	ITCH	0.3056
p.R1518H	ACH-002059	Leukemia	CCLE	PPFY	ITCH	0.3056
p.R1518H	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.3056
p.P1515S	TCGA-D5-6530	COAD	TCGA	PPFY	ITCH	0.6752
p.P1515S	TCGA-VQ-A8E0	STAD	TCGA	PPFY	ITCH	0.6752
p.P1515S	DO8312	COAD	ICGC	PPFY	ITCH	0.6752
p.P1515S	DO51757	STAD	ICGC	PPFY	ITCH	0.6752
p.V1508I	DO225207	BRCA	ICGC	PPFY	ITCH	0.1667
p.V1508I	SIDM00683	Prostate Carcinoma	GDSC	PPFY	ITCH	0.1667
p.R1518C	DO228544	GACA	ICGC	PPFY	ITCH	0.3056
p.V1504M	SIDM00281	Other Solid Cancers	GDSC	PPFY	ITCH	0.0556
p.V1504M	ACH-002100	Skin Cancer	CCLE	PPFY	ITCH	0.0556
p.V1504M	DJM-1	skin	COSMIC	PPFY	ITCH	0.0556
p.Y1517H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PPFY	ITCH	0.7229
p.Y1517H	ACH-000860	Lung Cancer	CCLE	PPFY	ITCH	0.7229
p.Y1517H	NCI-H358	lung	COSMIC	PPFY	ITCH	0.7229
p.A1527V	SIDM00660	Colorectal Carcinoma	GDSC	PPFY	ITCH	0.0556
p.A1527V	ACH-000985	Colon/Colorectal Cancer	CCLE	PPFY	ITCH	0.0556
p.A1527V	LS-411N	large_intestine	COSMIC	PPFY	ITCH	0.0556
p.V1508A	ACH-001130	Lymphoma	CCLE	PPFY	ITCH	0.1667
p.D1512G	ACH-001533	Lymphoma	CCLE	PPFY	ITCH	0.2778
p.L1517R	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.8428
p.Y1517C	NCI-H630	large_intestine	COSMIC	PPFY	ITCH	0.7087
p.R1517H	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.8244
p.Y1516C	NCI-H630	large_intestine	COSMIC	PPFY	ITCH	0.7087
p.R1521H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPFY	ITCH	0.2222
p.Y1516H	NCI-H358	lung	COSMIC	PPFY	ITCH	0.7229
p.A1526V	LS-411N	large_intestine	COSMIC	PPFY	ITCH	0.0833
p.I1504M	OVK-18	ovary	COSMIC	PPFY	ITCH	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17643	5,6-dihydroxyindole-2-carboxylic acid oxidase	ITCH	345:348	PPFY	ITCH,NEDD4	0.695	More...
P18583	Protein SON	ITCH	2136:2139	PPFY	ITCH,NEDD4	0.9982	More...
P78563	Double-stranded RNA-specific editase 1	ITCH	188:191	PPFY	ITCH,NEDD4	0.9978	More...
Q16644	MAP kinase-activated protein kinase 3	ITCH	240:243	PPFY	ITCH,NEDD4	0.6619	More...
Q5TBA9	Protein furry homolog	ITCH	1514:1517	PPFY	ITCH,NEDD4	0.7858	More...
Q5VTD9	Zinc finger protein Gfi-1b	ITCH	99:102	PPFY	ITCH,NEDD4	0.9889	More...
Q5VYJ5	MAM and LDL-receptor class A domain-containing protein 1	ITCH	103:106	PPFY	ITCH,NEDD4	0.6037	More...
Q6ZN30	Zinc finger protein basonuclin-2	ITCH	570:573	PPFY	ITCH,NEDD4	0.7924	More...
Q8IW41	MAP kinase-activated protein kinase 5	ITCH	239:242	PPFY	ITCH,NEDD4	0.887	More...
Q9UPX0	Protein turtle homolog B	ITCH	981:984	PPFY	ITCH,NEDD4	0.9332	More...
Q6ZTI6	Refilin-A	ITCH	38:41	PPFY	ITCH,NEDD4	0.9921	More...
Q7Z2T5	TRMT1-like protein	ITCH	632:635	PPFY	ITCH,NEDD4	0.8239	More...
A4D0V7	Cadherin-like and PC-esterase domain-containing protein 1	ITCH	104:107	PPFY	ITCH,NEDD4	0.9116	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	4949:4952	PPFY	ITCH,NEDD4	0.8101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPFY

Degron related mutations and impact score

Drug responses associated with FRY mutations

All proteins holding degron of PPFY