DegronMD

Uniprot ID: P17643

Source protein: 5,6-dihydroxyindole-2-carboxylic acid oxidase

Source gene: TYRP1

Class: ITCH

Location: 345:348

E3 ligase: ITCH,NEDD4

DEGRON score: 0.695

ASA_SCORE: 29.225

COIL: 0.7948

CONS_SCORE: 0.5175

DSS_SCORE: 0.3592

HELIX: 0.1293

FCONS_SCORE: 0.985

RIG_SCORE: 0.7584

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17643	5,6-dihydroxyindole-2-carboxylic acid oxidase	ITCH	345:348	PPFY	ITCH,NEDD4	0.695	More...
P18583	Protein SON	ITCH	2136:2139	PPFY	ITCH,NEDD4	0.9982	More...
P78563	Double-stranded RNA-specific editase 1	ITCH	188:191	PPFY	ITCH,NEDD4	0.9978	More...
Q16644	MAP kinase-activated protein kinase 3	ITCH	240:243	PPFY	ITCH,NEDD4	0.6619	More...
Q5TBA9	Protein furry homolog	ITCH	1514:1517	PPFY	ITCH,NEDD4	0.7858	More...
Q5VTD9	Zinc finger protein Gfi-1b	ITCH	99:102	PPFY	ITCH,NEDD4	0.9889	More...
Q5VYJ5	MAM and LDL-receptor class A domain-containing protein 1	ITCH	103:106	PPFY	ITCH,NEDD4	0.6037	More...
Q6ZN30	Zinc finger protein basonuclin-2	ITCH	570:573	PPFY	ITCH,NEDD4	0.7924	More...
Q8IW41	MAP kinase-activated protein kinase 5	ITCH	239:242	PPFY	ITCH,NEDD4	0.887	More...
Q9UPX0	Protein turtle homolog B	ITCH	981:984	PPFY	ITCH,NEDD4	0.9332	More...
Q6ZTI6	Refilin-A	ITCH	38:41	PPFY	ITCH,NEDD4	0.9921	More...
Q7Z2T5	TRMT1-like protein	ITCH	632:635	PPFY	ITCH,NEDD4	0.8239	More...
A4D0V7	Cadherin-like and PC-esterase domain-containing protein 1	ITCH	104:107	PPFY	ITCH,NEDD4	0.9116	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	4949:4952	PPFY	ITCH,NEDD4	0.8101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons