FUNCTION: Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulat...
FUNCTION: Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). {ECO:0000250|UniProtKB:P07147, ECO:0000269|PubMed:16704458, ECO:0000269|PubMed:22556244, ECO:0000269|PubMed:28661582, ECO:0000305|PubMed:16704458, ECO:0000305|PubMed:22556244, ECO:0000305|PubMed:23504663}.
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GO - Biological processes (BP):
acetoacetic acid metabolic process [GO:0043438]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023]...
acetoacetic acid metabolic process [GO:0043438]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023]
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GO - Molecular function (MF):
metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503]...
metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503]
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GO - Cellular component (CC):
clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]...
clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]
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