DegronMD - P78563(ADARB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P183S	TCGA-A5-A0G2	UCEC	TCGA	PPFY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.P183S	DO41235	UCEC	ICGC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.A186V	TCGA-AA-3947	COAD	TCGA	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.A186V	DO8192	COAD	ICGC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.A186V	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.A186V	SIDM00316	Glioblastoma	GDSC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.A186V	SIDM01622	Breast Carcinoma	GDSC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.A186V	SIDM00171	Colorectal Carcinoma	GDSC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.A186V	MEG-01	haematopoietic and lymphoid tissue	COSMIC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.A186V	YH-13	central nervous system	COSMIC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.2778
p.P183L	TCGA-AP-A1DK	UCEC	TCGA	PPFY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.P183L	DO42033	UCEC	ICGC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.R20C	TCGA-AX-A1C4	UCEC	TCGA	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation altering degron motif	0.719
p.R20C	DO42480	UCEC	ICGC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation altering degron motif	0.719
p.D23N	TCGA-BH-A0HF	BRCA	TCGA	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.25
p.D23N	DO1749	BRCA	ICGC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.25
p.G196V	TCGA-DU-7298	LGG	TCGA	PPFY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.G196V	DO22679	LGG	ICGC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.P189S	TCGA-FS-A1ZK	SKCM	TCGA	PPFY	ITCH	188:191	Mutation altering degron motif	0.6752
p.P189S	DO222837	MELA	ICGC	PPFY	ITCH	188:191	Mutation altering degron motif	0.6752
p.P189S	DO37474	SKCM	ICGC	PPFY	ITCH	188:191	Mutation altering degron motif	0.6752
p.P188S	DO227709	COCA	ICGC	PPFY	ITCH	188:191	Mutation altering degron motif	0.6752
p.R20H	DO234205	ESAD	ICGC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation altering degron motif	0.7133
p.G179C	DO229006	LICA	ICGC	PPFY	ITCH	188:191	Mutation rewiring degron network	0.0833
p.G30S	DO222908	MELA	ICGC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.0556
p.N8T	DO232224	PBCA	ICGC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation substituting flanking lysine	0.2222
p.E6K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation blocking phosphorylation signal	0.5
p.E6K	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation blocking phosphorylation signal	0.5
p.E6K	ACH-000995	Leukemia	CCLE	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation blocking phosphorylation signal	0.5
p.E6K	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation blocking phosphorylation signal	0.5
p.N24S	SIDM00193	Colorectal Carcinoma	GDSC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.2222
p.N24S	ACH-000991	Colon/Colorectal Cancer	CCLE	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.2222
p.N24S	SNU-81	large intestine	COSMIC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.2222
p.S10T	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.1667
p.S10T	NCI-H1734	lung	COSMIC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.1667
p.L7P	HT-115	large intestine	COSMIC	VKENR	DEG_APCC_KENBOX_2	16:20	Mutation rewiring degron network	0.0833

Kaplan plot for ADARB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADARB1

UniProt ID: P78563

Entrez ID: 104

Protein name: Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADARB1 in