DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VKENR
Uniprot ID:
P78563
Source protein:
Double-stranded RNA-specific editase 1
Source gene:
ADARB1
Class:
DEG_APCC_KENBOX_2
Location:
16:20
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9673
ASA_SCORE:
107.22
COIL:
0.5838
CONS_SCORE:
0.4269
DSS_SCORE:
0.7437
HELIX:
0.3966
FCONS_SCORE:
1.0006
RIG_SCORE:
0.6554
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R20C
TCGA-AX-A1C4
UCEC
TCGA
VKENR
DEG_APCC_KENBOX_2
0.719
p.R20C
DO42480
UCEC
ICGC
VKENR
DEG_APCC_KENBOX_2
0.719
p.D23N
TCGA-BH-A0HF
BRCA
TCGA
VKENR
DEG_APCC_KENBOX_2
0.25
p.D23N
DO1749
BRCA
ICGC
VKENR
DEG_APCC_KENBOX_2
0.25
p.R20H
DO234205
ESAD
ICGC
VKENR
DEG_APCC_KENBOX_2
0.7133
p.G30S
DO222908
MELA
ICGC
VKENR
DEG_APCC_KENBOX_2
0.0556
p.N8T
DO232224
PBCA
ICGC
VKENR
DEG_APCC_KENBOX_2
0.2222
p.E6K
SIDM01016
T-Lymphoblastic Leukemia
GDSC
VKENR
DEG_APCC_KENBOX_2
0.5
p.E6K
SIDM01263
T-Lymphoblastic Leukemia
GDSC
VKENR
DEG_APCC_KENBOX_2
0.5
p.E6K
ACH-000995
Leukemia
CCLE
VKENR
DEG_APCC_KENBOX_2
0.5
p.E6K
Jurkat
haematopoietic_and_lymphoid_tissue
COSMIC
VKENR
DEG_APCC_KENBOX_2
0.5
p.N24S
SIDM00193
Colorectal Carcinoma
GDSC
VKENR
DEG_APCC_KENBOX_2
0.2222
p.N24S
ACH-000991
Colon/Colorectal Cancer
CCLE
VKENR
DEG_APCC_KENBOX_2
0.2222
p.N24S
SNU-81
large_intestine
COSMIC
VKENR
DEG_APCC_KENBOX_2
0.2222
p.S10T
SIDM00739
Non-Small Cell Lung Carcinoma
GDSC
VKENR
DEG_APCC_KENBOX_2
0.1667
p.S10T
NCI-H1734
lung
COSMIC
VKENR
DEG_APCC_KENBOX_2
0.1667
p.L7P
HT-115
large_intestine
COSMIC
VKENR
DEG_APCC_KENBOX_2
0.0833
Drug responses associated with ADARB1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKENR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P78563
Double-stranded RNA-specific editase 1
DEG_APCC_KENBOX_2
16:20
VKENR
APC,CDC20,FZR1
0.9673
More...
Q9NS39
Double-stranded RNA-specific editase B2
DEG_APCC_KENBOX_2
69:73
VKENR
APC,CDC20,FZR1
0.7447
More...