DegronMD - Q9NS39(ADARB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T61N	TCGA-37-5819	LUSC	TCGA	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.1111
p.T61N	DO26479	LUSC	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.1111
p.G607S	TCGA-AX-A2HD	UCEC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.0833
p.R629H	TCGA-BK-A26L	UCEC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.R629H	TCGA-VQ-A91D	STAD	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.R629C	TCGA-BT-A2LD	BLCA	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.R629C	SIDM00973	Melanoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.R629C	SIDM00660	Colorectal Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.R629C	SIDM00995	Other Solid Cancers	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.R629C	SIDM01229	Neuroblastoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.R629C	SIDM01042	Breast Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1944
p.S634L	TCGA-EB-A4IS	SKCM	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation blocking phosphorylation signal	0.5
p.S634L	SIDM00576	Acute Myeloid Leukemia	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation blocking phosphorylation signal	0.5
p.S634L	ACH-002290	Leukemia	CCLE	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation blocking phosphorylation signal	0.5
p.S634L	NKM-1	haematopoietic and lymphoid tissue	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation blocking phosphorylation signal	0.5
p.P631L	TCGA-HU-A4G8	STAD	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1389
p.P631L	TCGA-VB-A8QN	DLBC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1389
p.E627K	TCGA-SI-A71O	SARC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.25
p.V75L	DO536	BLCA	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.2778
p.S66R	DO1290	BRCA	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.25
p.A79V	DO222723	COCA	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.1667
p.A65D	DO228976	LICA	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.2222
p.P82Q	DO229022	LICA	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.0833
p.P68H	DO229024	LICA	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.3056
p.D60N	DO231799	LINC	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.0833
p.A67V	DO232224	PBCA	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.2778
p.A80V	DO38727	STAD	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.1389
p.A80V	SIDM01619	Endometrial Carcinoma	GDSC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.1389
p.V73I	DO40889	UCEC	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation altering degron motif	0.7076
p.L80F	DO41331	UCEC	ICGC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.1389
p.R614W	SIDM00993	Plasma Cell Myeloma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	SIDM00578	Neuroblastoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	SIDM01151	Hepatocellular Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	SIDM01242	Melanoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	SIDM00466	Ovarian Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	SNU-182	liver	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	MMAC-SF	skin	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	AMO-1	haematopoietic and lymphoid tissue	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R614W	OVKATE	ovary	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.R73H	ACH-000985	Colon/Colorectal Cancer	CCLE	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation altering degron motif	0.7133
p.R67W	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.2778
p.S66P	MCC13	skin	COSMIC	VKENR	DEG_APCC_KENBOX_2	69:73	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADARB2

UniProt ID: Q9NS39

Entrez ID: 105

Protein name: Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADARB2 in