DegronMD

Uniprot ID: Q9NS39

Source protein: Double-stranded RNA-specific editase B2

Source gene: ADARB2

Class: DEG_APCC_DBOX_1

Location: 616:624

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8212

ASA_SCORE: 57.2667

COIL: 0.6497

CONS_SCORE: 0.3872

DSS_SCORE: 0.5103

HELIX: 0.0687

FCONS_SCORE: 1.0288

RIG_SCORE: 0.6883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G607S	TCGA-AX-A2HD	UCEC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.0833
p.R629H	TCGA-BK-A26L	UCEC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.R629H	TCGA-VQ-A91D	STAD	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.R629C	TCGA-BT-A2LD	BLCA	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.R629C	SIDM00973	Melanoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.R629C	SIDM00660	Colorectal Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.R629C	SIDM00995	Other Solid Cancers	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.R629C	SIDM01229	Neuroblastoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.R629C	SIDM01042	Breast Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.1944
p.S634L	TCGA-EB-A4IS	SKCM	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.5
p.S634L	SIDM00576	Acute Myeloid Leukemia	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.5
p.S634L	ACH-002290	Leukemia	CCLE	NRPLLSGVS	DEG_APCC_DBOX_1	0.5
p.S634L	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	0.5
p.P631L	TCGA-HU-A4G8	STAD	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.1389
p.P631L	TCGA-VB-A8QN	DLBC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.1389
p.E627K	TCGA-SI-A71O	SARC	TCGA	NRPLLSGVS	DEG_APCC_DBOX_1	0.25
p.R614W	SIDM00993	Plasma Cell Myeloma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	SIDM00578	Neuroblastoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	SIDM01151	Hepatocellular Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	SIDM01242	Melanoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	SIDM00466	Ovarian Carcinoma	GDSC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	SNU-182	liver	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	MMAC-SF	skin	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778
p.R614W	OVKATE	ovary	COSMIC	NRPLLSGVS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS39	Double-stranded RNA-specific editase B2	DEG_APCC_DBOX_1	616:624	NRPLLSGVS	APC,CDC20,FZR1	0.8212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRPLLSGVS

Degron related mutations and impact score

Drug responses associated with ADARB2 mutations

All proteins holding degron of NRPLLSGVS