DegronMD

Uniprot ID: Q9NS39

Source protein: Double-stranded RNA-specific editase B2

Source gene: ADARB2

Class: DEG_APCC_KENBOX_2

Location: 69:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7447

ASA_SCORE: 108.06

COIL: 0.6426

CONS_SCORE: 0.1691

DSS_SCORE: 0.6172

HELIX: 0.2638

FCONS_SCORE: 1.0402

RIG_SCORE: 0.7128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T61N	TCGA-37-5819	LUSC	TCGA	VKENR	DEG_APCC_KENBOX_2	0.1111
p.T61N	DO26479	LUSC	ICGC	VKENR	DEG_APCC_KENBOX_2	0.1111
p.V75L	DO536	BLCA	ICGC	VKENR	DEG_APCC_KENBOX_2	0.2778
p.S66R	DO1290	BRCA	ICGC	VKENR	DEG_APCC_KENBOX_2	0.25
p.A79V	DO222723	COCA	ICGC	VKENR	DEG_APCC_KENBOX_2	0.1667
p.A65D	DO228976	LICA	ICGC	VKENR	DEG_APCC_KENBOX_2	0.2222
p.P82Q	DO229022	LICA	ICGC	VKENR	DEG_APCC_KENBOX_2	0.0833
p.P68H	DO229024	LICA	ICGC	VKENR	DEG_APCC_KENBOX_2	0.3056
p.D60N	DO231799	LINC	ICGC	VKENR	DEG_APCC_KENBOX_2	0.0833
p.A67V	DO232224	PBCA	ICGC	VKENR	DEG_APCC_KENBOX_2	0.2778
p.A80V	DO38727	STAD	ICGC	VKENR	DEG_APCC_KENBOX_2	0.1389
p.A80V	SIDM01619	Endometrial Carcinoma	GDSC	VKENR	DEG_APCC_KENBOX_2	0.1389
p.V73I	DO40889	UCEC	ICGC	VKENR	DEG_APCC_KENBOX_2	0.7076
p.L80F	DO41331	UCEC	ICGC	VKENR	DEG_APCC_KENBOX_2	0.1389
p.R73H	ACH-000985	Colon/Colorectal Cancer	CCLE	VKENR	DEG_APCC_KENBOX_2	0.7133
p.R67W	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VKENR	DEG_APCC_KENBOX_2	0.2778
p.S66P	MCC13	skin	COSMIC	VKENR	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78563	Double-stranded RNA-specific editase 1	DEG_APCC_KENBOX_2	16:20	VKENR	APC,CDC20,FZR1	0.9673	More...
Q9NS39	Double-stranded RNA-specific editase B2	DEG_APCC_KENBOX_2	69:73	VKENR	APC,CDC20,FZR1	0.7447	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons