DegronMD - Q8N9V7(TOPAZ1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K765T	TCGA-AJ-A3EL	UCEC	TCGA	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.6195
p.K765T	DO41542	UCEC	ICGC	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.6195
p.S780N	TCGA-AP-A1DV	UCEC	TCGA	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.0833
p.S780N	DO43186	UCEC	ICGC	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.0833
p.K638E	TCGA-AY-6197	COAD	TCGA	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.591
p.K638E	DO9956	COAD	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.591
p.G741E	TCGA-B2-3923	KIRC	TCGA	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1667
p.G741E	DO18889	KIRC	ICGC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1667
p.L636V	TCGA-B5-A0JY	UCEC	TCGA	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6765
p.L636V	DO43041	UCEC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6765
p.N258K	TCGA-B5-A3FA	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.25
p.N258K	DO52402	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.25
p.V726I	TCGA-B5-A3FA	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1944
p.V726I	DO25189	LUAD	ICGC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1944
p.V726I	DO52402	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1944
p.D273G	TCGA-D1-A16R	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1111
p.D273G	DO41831	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1111
p.F259L	TCGA-D1-A16X	UCEC	TCGA	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.2778
p.F259L	DO41799	UCEC	ICGC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.2778
p.T637M	TCGA-EO-A3AV	UCEC	TCGA	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6312
p.T637M	DO52412	UCEC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6312
p.T637M	SIDM02043	Colorectal Carcinoma	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6312
p.F259V	TCGA-F5-6814	READ	TCGA	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.2778
p.F259V	DO36556	READ	ICGC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.2778
p.A756D	TCGA-XR-A8TD	LIHC	TCGA	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.1389
p.A756D	DO223921	LIHC	ICGC	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.1389
p.S770Y	DO222884	COCA	ICGC	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.712
p.T774A	DO233693	GACA	ICGC	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.25
p.G648V	DO229028	LICA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1111
p.G648V	DO229045	LICA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1111
p.K629Q	DO231652	LINC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation substituting flanking lysine	0.3611
p.A632D	DO230940	LUSC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6682
p.A632D	DO224584	LUSC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6682
p.T774I	DO231141	LUSC	ICGC	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.25
p.G634E	DO220862	MELA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6087
p.M738I	DO220881	MELA	ICGC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.25
p.K629E	DO222599	MELA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation substituting flanking lysine	0.3611
p.S766F	DO222527	MELA	ICGC	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.6871
p.S766F	SIDM01161	Other Sarcomas	GDSC	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.6871
p.S766F	ACH-001274	Sarcoma	CCLE	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.6871
p.S766F	SW982	soft tissue	COSMIC	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.6871
p.R633S	DO222837	MELA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.7427
p.A643V	DO35210	PACA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.25
p.A643V	SIDM00282	Colorectal Carcinoma	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.25
p.G627R	DO47542	SKCM	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1944
p.S624R	DO229257	THCA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1111
p.T622N	DO229250	THCA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.0556
p.K764M	SIDM02064	Colorectal Carcinoma	GDSC	NKKSYSISP	CBL_PTK	763:771	Mutation altering degron motif	0.6951
p.C252F	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.0833
p.C252F	ACH-000706	Lung Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.0833
p.C252F	EKVX	lung	COSMIC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.0833
p.M737V	SIDM00969	Ovarian Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.2778
p.M737V	SIDM00254	Neuroblastoma	GDSC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.2778
p.M737V	SIDM00721	Small Cell Lung Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.2778
p.K732E	SIDM00938	Breast Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation altering degron motif	0.7022
p.K732E	ACH-000902	Breast Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation altering degron motif	0.7022
p.K732E	CAL-148	breast	COSMIC	SKENV	DEG_APCC_KENBOX_2	731:735	Mutation altering degron motif	0.7022
p.E263K	SIDM00789	Colorectal Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.7022
p.E263K	ACH-000997	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.7022
p.E263K	ACH-001061	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.7022
p.E263K	HCT-15	large intestine	COSMIC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.7022
p.T626M	SIDM01113	Other Sarcomas	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1667
p.T626M	SIDM01051	Ovarian Carcinoma	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1667
p.L265F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.587
p.L265F	SIDM00937	Oral Cavity Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.587
p.L265F	CAL-27	upper aerodigestive tract	COSMIC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.587
p.L265F	NCI-H441	lung	COSMIC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.587
p.K261N	SIDM00272	Breast Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.5806
p.K261N	ACH-000910	Breast Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.5806
p.K261N	MDA-MB-453	breast	COSMIC	KKENL	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.5806
p.P753L	SIDM00140	Melanoma	GDSC	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.0556
p.P753L	COLO-792	skin	COSMIC	NKKSYSISP	CBL_PTK	763:771	Mutation rewiring degron network	0.0556
p.T626A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOPAZ1

UniProt ID: Q8N9V7

Entrez ID: 375337

Protein name: Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOPAZ1 in