DegronMD

Uniprot ID: Q8N9V7

Source protein: Protein TOPAZ1

Source gene: TOPAZ1

Class: DEG_APCC_DBOX_1

Location: 632:640

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9896

ASA_SCORE: 99.0667

COIL: 0.7583

CONS_SCORE: 0.841

DSS_SCORE: 0.5211

HELIX: 0.1551

FCONS_SCORE: 1.051

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K638E	TCGA-AY-6197	COAD	TCGA	ARGNLTKLN	DEG_APCC_DBOX_1	0.591
p.K638E	DO9956	COAD	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.591
p.L636V	TCGA-B5-A0JY	UCEC	TCGA	ARGNLTKLN	DEG_APCC_DBOX_1	0.6765
p.L636V	DO43041	UCEC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.6765
p.T637M	TCGA-EO-A3AV	UCEC	TCGA	ARGNLTKLN	DEG_APCC_DBOX_1	0.6312
p.T637M	DO52412	UCEC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.6312
p.T637M	SIDM02043	Colorectal Carcinoma	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	0.6312
p.G648V	DO229028	LICA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.1111
p.G648V	DO229045	LICA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.1111
p.K629Q	DO231652	LINC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.3611
p.A632D	DO230940	LUSC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.6682
p.A632D	DO224584	LUSC	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.6682
p.G634E	DO220862	MELA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.6087
p.K629E	DO222599	MELA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.3611
p.R633S	DO222837	MELA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.7427
p.A643V	DO35210	PACA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.25
p.A643V	SIDM00282	Colorectal Carcinoma	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	0.25
p.G627R	DO47542	SKCM	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.1944
p.S624R	DO229257	THCA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.1111
p.T622N	DO229250	THCA	ICGC	ARGNLTKLN	DEG_APCC_DBOX_1	0.0556
p.T626M	SIDM01113	Other Sarcomas	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	0.1667
p.T626M	SIDM01051	Ovarian Carcinoma	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	0.1667
p.T626A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARGNLTKLN	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9V7	Protein TOPAZ1	DEG_APCC_DBOX_1	632:640	ARGNLTKLN	APC,CDC20,FZR1	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons