DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NKKSYSISP
Uniprot ID:
Q8N9V7
Source protein:
Protein TOPAZ1
Source gene:
TOPAZ1
Class:
CBL_PTK
Location:
763:771
E3 ligase:
CBL
DEGRON score:
0.8478
ASA_SCORE:
100
COIL:
0.822
CONS_SCORE:
0.5965
DSS_SCORE:
0.4107
HELIX:
0.1352
FCONS_SCORE:
0.9523
RIG_SCORE:
0.7026
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K765T
TCGA-AJ-A3EL
UCEC
TCGA
NKKSYSISP
CBL_PTK
0.6195
p.K765T
DO41542
UCEC
ICGC
NKKSYSISP
CBL_PTK
0.6195
p.S780N
TCGA-AP-A1DV
UCEC
TCGA
NKKSYSISP
CBL_PTK
0.0833
p.S780N
DO43186
UCEC
ICGC
NKKSYSISP
CBL_PTK
0.0833
p.A756D
TCGA-XR-A8TD
LIHC
TCGA
NKKSYSISP
CBL_PTK
0.1389
p.A756D
DO223921
LIHC
ICGC
NKKSYSISP
CBL_PTK
0.1389
p.S770Y
DO222884
COCA
ICGC
NKKSYSISP
CBL_PTK
0.712
p.T774A
DO233693
GACA
ICGC
NKKSYSISP
CBL_PTK
0.25
p.T774I
DO231141
LUSC
ICGC
NKKSYSISP
CBL_PTK
0.25
p.S766F
DO222527
MELA
ICGC
NKKSYSISP
CBL_PTK
0.6871
p.S766F
SIDM01161
Other Sarcomas
GDSC
NKKSYSISP
CBL_PTK
0.6871
p.S766F
ACH-001274
Sarcoma
CCLE
NKKSYSISP
CBL_PTK
0.6871
p.S766F
SW982
soft_tissue
COSMIC
NKKSYSISP
CBL_PTK
0.6871
p.K764M
SIDM02064
Colorectal Carcinoma
GDSC
NKKSYSISP
CBL_PTK
0.6951
p.P753L
SIDM00140
Melanoma
GDSC
NKKSYSISP
CBL_PTK
0.0556
p.P753L
COLO-792
skin
COSMIC
NKKSYSISP
CBL_PTK
0.0556
Drug responses associated with TOPAZ1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKKSYSISP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N9V7
Protein TOPAZ1
CBL_PTK
763:771
NKKSYSISP
CBL
0.8478
More...
