DegronMD

Uniprot ID: Q8N9V7

Source protein: Protein TOPAZ1

Source gene: TOPAZ1

Class: DEG_APCC_KENBOX_2

Location: 731:735

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8214

ASA_SCORE: 102.26

COIL: 0.7496

CONS_SCORE: 0.6208

DSS_SCORE: 0.5225

HELIX: 0.2022

FCONS_SCORE: 1.0256

RIG_SCORE: 0.7361

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G741E	TCGA-B2-3923	KIRC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.1667
p.G741E	DO18889	KIRC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1667
p.V726I	TCGA-B5-A3FA	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.1944
p.V726I	DO25189	LUAD	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1944
p.V726I	DO52402	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1944
p.M738I	DO220881	MELA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.25
p.M737V	SIDM00969	Ovarian Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.2778
p.M737V	SIDM00254	Neuroblastoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.2778
p.M737V	SIDM00721	Small Cell Lung Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.2778
p.K732E	SIDM00938	Breast Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.7022
p.K732E	ACH-000902	Breast Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.7022
p.K732E	CAL-148	breast	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	25:29	SKENV	APC,CDC20,FZR1	0.997	More...
Q58F21	Bromodomain testis-specific protein	DEG_APCC_KENBOX_2	683:687	SKENV	APC,CDC20,FZR1	0.9942	More...
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_APCC_KENBOX_2	1123:1127	SKENV	APC,CDC20,FZR1	0.7191	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	1375:1379	SKENV	APC,CDC20,FZR1	0.5524	More...
Q8TBA6	Golgin subfamily A member 5	DEG_APCC_KENBOX_2	198:202	SKENV	APC,CDC20,FZR1	0.9905	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_APCC_KENBOX_2	1525:1529	SKENV	APC,CDC20,FZR1	0.8967	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_APCC_KENBOX_2	442:446	SKENV	APC,CDC20,FZR1	0.9903	More...
Q2T9K0	Transmembrane protein 44	DEG_APCC_KENBOX_2	450:454	SKENV	APC,CDC20,FZR1	0.6922	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	731:735	SKENV	APC,CDC20,FZR1	0.8214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons